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UnknownApplication of bi-clustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials.
Not available
S-EPMC5683856 | biostudies-literature
TranscriptomicsGenetic toxicology and toxicogenomic analysis of 3 cigarette smoke condensates in vitro reveals few differences between high and low tar brands
This experiment investigated the response of mouse pulmonary epithelial cells in culture (FE1 cell line) to 3 different brands of cigarette smoke condensate. The three brands represent a full flavour, regular and king-size light cigarettes. These vary in some key chemical consistuents. Brand #1 has ...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-30079 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of cultured lung epithelial cells exposed to multiwalled carbon nanotubes (Mitsui7)
There is great interest in substituting animal with in vitro experimentation in human health risk assessment, but there are rather few comparisons of in vitro and in vivo biological responses to engineered nanomaterials (ENM). We used high-content genomics tools, to compare in vivo pulmonary respon...
ORGANISM(S): Mus musculus 
2015-05-05 | E-GEOD-46999 | biostudies-arrayexpress
UnknownAcute Toxicity of Metal Oxide Nanoparticles-Role of Intracellular Localization In Vitro in Lung Epithelial Cells.
Not available
S-EPMC12428783 | biostudies-literature
UnknownApplication of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials.
Not available
S-EPMC4734442 | biostudies-literature
TranscriptomicsmiRNA 135b regulation of inflammation
RT-PCR analysis of inflammatory cytokines and receptors in pEGP-miR-135b over-expressing cells compard to controls (pEGP-miR-null) using pathway-specific PCR arrays for the evaluation of mouse inflammatory cytokines and receptors (#PAMM-011D). qPCR array gene expression profiling. This experiment ex...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43681 | biostudies-arrayexpress
TranscriptomicsmiRNA 135b regulation by Il1r1 during inflammation
RT-PCR analysis of inflammatory cytokines and receptors following Il1alpha treatment of pEGP-miR-135b over-expressing cells compard to controls (pEGP-miR-null) using pathway-specific PCR arrays for the evaluation of mouse inflammatory cytokines and receptors (#PAMM-011D). qPCR array gene expression ...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43683 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Apoe knockouts treated with SRM2975 and C57Bl/6 mice treated with exhaust particles reveals Serum amyloid and serum amyloid P are not induced in response to diesel exhaust particles or carbon black
W evaluated an experimental particle exposure model, including markers of the acute phase system assessed as the hepatic mRNA expression of Sap, the murine homologue of CRP, and Saa1 and Saa3. Experiment Overall Design: 12-13 weeks old Apoe knockout mice (C57BL/6-Apoe tm1) mice were injected intrape...
ORGANISM(S): Mus musculus 
2009-05-02 | E-GEOD-11346 | biostudies-arrayexpress
TranscriptomicsPulmonary gene expression in MutaTMMouse orally gavaged with three doses of benzo(a)pyrene and vehicle control
In this study, we investigate mRNA profiles in lung of mice exposed to benzo(a)pyrene. Male mice were exposed to three doses (25, 50, and 75 mg/kg/day BaP) for 28 days and profiles were examined three days post-exposure. Our analyses reveal that BaP causes pulmonary specific cellular transformation ...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-35718 | biostudies-arrayexpress
TranscriptomicsSub-chronic forestomach transcriptional response in adult male MutaTMMouse following oral exposure to benzo(a)pyrene
Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male MutaTMMouse were exposed to three doses of benzo(a)pyrene or vehicle cont...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-43438 | biostudies-arrayexpress
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