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TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
UnknownAspirin versus placebo for the treatment of venous leg ulcers-a phase II, pilot, randomised trial (AVURT).
Not available
S-EPMC6660698 | biostudies-literature
TranscriptomicsSerous ovarian benign tumor and type II carcinoma data set for expression and paracrine signaling investigation
A data set of normal epithelium, serous ovarian surface epithelial-stromal tumors (benign and type II malignancies), stroma distal to tumor, and stroma adjacent to tumor (50 samples total). Additional cel files are included which represent replicate sampling from patients, and cel files that failed ...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-29156 | biostudies-arrayexpress
UnknownTracking Children's Mental Health in the 21st Century: Lessons from the 2014 OCHS.
Not available
S-EPMC6463360 | biostudies-literature
UnknownMeta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Not available
S-EPMC3354734 | biostudies-literature
UnknownMutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.
Not available
S-EPMC2677501 | biostudies-literature
UnknownVariation in GIGYF2 is not associated with Parkinson disease.
Not available
S-EPMC2690967 | biostudies-literature
UnknownParkin dosage mutations have greater pathogenicity in familial PD than simple sequence mutations.
Not available
S-EPMC2715211 | biostudies-literature
UnknownCopy number variation in familial Parkinson disease.
Not available
S-EPMC3149037 | biostudies-literature
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