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MetabolomicsToxicometabolomics of the new psychoactive substances α-PBP and α-PEP studied in HepaRG cell incubates by means of untargeted metabolomics revealed unexpected amino acid adducts
Toxicometabolomics, essentially applying metabolomics to toxicology of endogenous compounds such as drugs of abuse or new psychoactive substances (NPS), can be investigated by using different in vitro models and dedicated metabolomics techniques to enhance the number of relevant findings. The presen...
2023-10-10 | MTBLS1481 | MetaboLights
UnknownUncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis.
Not available
S-EPMC10902879 | biostudies-literature
UnknownGenome-wide association study of preserved ratio impaired spirometry (PRISm).
Not available
S-EPMC10765494 | biostudies-literature
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
UnknownShared heritability and functional enrichment across six solid cancers.
Not available
S-EPMC6347624 | biostudies-literature
UnknownPhase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma.
Not available
S-EPMC3179270 | biostudies-literature
MetabolomicsMetabolite profiling of Arabidopsis mutants of enzymes of lower glycolysis
We have previously shown that in Arabidopsis the three enzymes of lower glycolysis phosphoglycerate mutase (PGAM), enolase and pyruvate kinase form a complex which play an important role in co-sub-cellar localization the mitochondria to the chloroplast. Given that their metabolites of these mutants,...
2022-10-10 | MTBLS4066 | MetaboLights
UnknownGenome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.
Not available
S-EPMC5537640 | biostudies-literature
UnknownA unitary anesthetic binding site at high resolution.
Not available
S-EPMC2782011 | biostudies-literature
UnknownGenome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.
Not available
S-EPMC7305950 | biostudies-literature
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