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ProteomicsProteome profiling of extracellular vesicles from neurosurgical aspirates identifies CCT6A as a potential glioblastoma biomarker with prognostic significance
Glioblastoma, WHO-grade IV glioma, carries a dismal prognosis owing to its infiltrative growth rates and limited treatment options. Glioblastoma-derived extracellular vesicles (EVs; 30-1000nm membranous particles) influence the microenvironment to mediate tumour aggressiveness and carry oncogenic ca...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD010247 | Pride
Human Tumour Brain Extracellular vesicles Cct6a Glioblastoma Biomarker Glioma Exosomes Lc-ms/ms 
ProteomicsSize matters: Biomolecular compositions of small and large extracellular vesicles in the urine of glioblastoma patients
Glioblastoma is a fatal and devastating primary brain tumour that poses significant challenges to accurate tumour monitoring and patient treatment. Substantial efforts are underway to develop accurate non-invasive liquid biopsy methods that can routinely assess glioblastoma markers in patient body f...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051553 | Pride
Gliioblastoma Extracellular vesicles Liquid biopsy Urine 
ProteomicsGlioblastoma biomarkers in urinary extracellular vesicles reveal the potential for a ‘liquid gold’ biopsy
Background: Biomarkers that reflect glioblastoma tumour activity and treatment response are urgently needed to help guide clinical management, particularly for recurrent disease. As the urinary system is a major clearance route of circulating extracellular vesicles (EVs; 30-1000 nm nanoparticles) we...
ORGANISM(S): Homo sapiens (Human) 
2024-04-18 | PXD046511 | Pride
Proteomics Urine Dia Extracellular vesicles Glioblastoma Liquid biopsy 
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