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ProteomicsTumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma
M2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment drive their formation, the role of PDAC-derived exosomes in this process remains unclear. We aim to...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD056403 | Pride
Exosome Cct6a Pdac 
ProteomicsTumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma
CCT6A is a key subunit of the TRiC complex and is responsible for the folding and maturation of approximately 10% of newly synthesized proteins in cells. Given that different TRiC subunits exhibit substrate specificity, we hypothesized that CCT6A might act as a specific binding subunit. To test this...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD057101 | Pride
Human  pdac cell line  lc-ms  knockdown of cct6a 
UnknownCCT6A, a novel prognostic biomarker for Ewing sarcoma.
Not available
S-EPMC7850773 | biostudies-literature
TranscriptomicsTumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma [human RNA-seq]
M2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment drive their formation, the role of PDAC-derived exosomes in this process remains unclear. We aim to...
ORGANISM(S): Homo sapiens 
2025-04-06 | GSE278909 | GEO
TranscriptomicsTumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma [mouse RNA-seq]
M2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment drive their formation, the role of PDAC-derived exosomes in this process remains unclear. We aim to...
ORGANISM(S): Mus musculus 
2025-03-28 | GSE278339 | GEO
ProteomicsProteome profiling of extracellular vesicles from neurosurgical aspirates identifies CCT6A as a potential glioblastoma biomarker with prognostic significance
Glioblastoma, WHO-grade IV glioma, carries a dismal prognosis owing to its infiltrative growth rates and limited treatment options. Glioblastoma-derived extracellular vesicles (EVs; 30-1000nm membranous particles) influence the microenvironment to mediate tumour aggressiveness and carry oncogenic ca...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD010247 | Pride
Human Tumour Brain Extracellular vesicles Cct6a Glioblastoma Biomarker Glioma Exosomes Lc-ms/ms 
UnknownCCT6A knockdown suppresses osteosarcoma cell growth and Akt pathway activation in vitro.
Not available
S-EPMC9803215 | biostudies-literature
GenomicsTumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma [human RNA-seq]
Tumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma [human RNA-seq]
PRJNA1169553 | ENA
UnknownCCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Not available
S-EPMC11574388 | biostudies-literature
UnknownCCT6A functions as promising diagnostic biomarker and promotes cell proliferation in colorectal cancer.
Not available
S-EPMC11493007 | biostudies-literature
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