Dataset Information

Tumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma

ABSTRACT: CCT6A is a key subunit of the TRiC complex and is responsible for the folding and maturation of approximately 10% of newly synthesized proteins in cells. Given that different TRiC subunits exhibit substrate specificity, we hypothesized that CCT6A might act as a specific binding subunit. To test this hypothesis, we performed interactome analysis to identify proteins that interact with CCT6A. Among the identified binding partners, seven out of eight CCT subunits were detected, confirming the reliability of the interactome

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Malignant Cell, Cell Culture

DISEASE(S): Pancreatic Carcinoma

SUBMITTER: Minghe Zhang

LAB HEAD: Yufeng, Yuan

PROVIDER: PXD057101 | Pride | 2025-05-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	TEclipse_FAIMS_JD_X0064240801_Z01_C6.raw	Raw
	TEclipse_FAIMS_JD_X0064240801_Z01_C6_PeptideGroups.xlsx	Xlsx
	TEclipse_FAIMS_JD_X0064240801_Z01_C6_Proteins.xlsx	Xlsx
	TEclipse_FAIMS_JD_X0064240801_Z01_IgG.raw	Raw
	TEclipse_FAIMS_JD_X0064240801_Z01_IgG_PeptideGroups.xlsx	Xlsx

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Publications

Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma.

Ma Tianyin T Guo Wing-Wa WW Zhang Minghe M He Wenzhi W Dongzhi Cairang C Gongye Xiangdong X Xia Peng P Chai Yibo Y Chen Zhang Z Zhu Yimin Y Qu Chengming C Liu Jie J Yang Zhiyong Z Ma Weijie W Tian Ming M Yuan Yufeng Y

Cell death & disease 20250515 1

M2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment (TME) drive their formation, the role of PDAC-derived exosomes in this process remains unclear. We aim to clarify the regulatory impacts of tumor-derived exosomes to TAMs. After the intratumoral injection to subcutaneous tumor of C57BL/6 mice, we demonstrated PDAC-derived exosomes exacerbate PDAC p ...[more]

PMID: 40374617

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