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MetabolomicsPhysiological extremes of the human blood metabolome: A metabolomics analysis of highly glycolytic, oxidative, and anabolic athletes
Human metabolism is highly variable. At one end of the spectrum, defects of enzymes, transporters, and metabolic regulation result in metabolic diseases such as diabetes mellitus or inborn errors of metabolism. At the other end of the spectrum, favorable genetics and years of training combine to res...
2022-02-07 | MTBLS2104 | MetaboLights
MetabolomicsMTBLS12814: Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies

Background

Regular physical activity is known to benefit health but the long-term effects of specific exercise training on human metabolism remain incompletely described. In this study, we comprehensively characterized the blood metabolomes of male athletes with distinct exercise-adapted me...

2026-03-13 | MTBLS12814 | MetaboLights
UnknownInhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model
Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression have remained incompletely understood. We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis, is a...
S-SCDT-EMM-2018-09665 | biostudies-other
UnknownMicroglial PD-1 modulates neuroinflammation and Alzheimer's disease pathology by astrocytic PD-L1
Neuroinflammation, a pathogenic component of Alzheimer disease (AD), may limit the ability of the brain to clear deposits and debris. Tight control of the immune system may therefore be key to sustain the ability of the brain for repair and clearance. Here we report that PD-L1 on astrocytes and its ...
S-SCDT-EMBOJ-2021-108662 | biostudies-other
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