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ProteomicsPlasmodium sporozoites require the protein B9 to invade hepatocytes
Here we report that the B9 protein, a member of the 6-cysteine domain protein family, is secreted from sporozoite micronemes and is required for productive invasion of hepatocytes.
ORGANISM(S): Homo sapiens (Human) Plasmodium berghei 
2023-03-11 | PXD034830 | Pride
Malaria B9 protein Hepatocyte Beta-propeller domain. Invasion Plasmodium sporozoites 
ProteomicsThe claudin-like apicomplexan microneme protein is essential for Plasmodium berghei sporozoite infectivity in the mosquito and mammalian hosts
Here we characterize the function of a microneme protein expressed both in merozoites and sporozoites, the claudin-like protein CLAMP. We used a conditional genome editing strategy in a rodent malaria model to generate CLAMP-deficient sporozoites. In the absence of CLAMP, sporozoites failed to invad...
ORGANISM(S): Plasmodium berghei ANKA 
2023-05-10 | PXD037561 | Pride
Plasmodium  malaria  sporozoites  conditional mutagenesis  clamp 
ProteomicsThe AMA1-RON complex drives Plasmodium sporozoite invasion in the mosquito and mammalian hosts
Sporozoites and merozoites share a number of proteins that are expressed by both stages, including the Apical Membrane Antigen 1 (AMA1) and the Rhoptry Neck Proteins (RONs). Although AMA1 and RONs are essential for merozoite invasion of erythrocytes during asexual blood stage replication of the mala...
ORGANISM(S): Plasmodium berghei ANKA 
2022-08-12 | PXD031463 | Pride
Plasmodium Malaria Rons. Sporozoites Ama1 
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