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ProteomicsMT-MAMS: protein methyltransferase motif analysis by mass spectrometry
Protein methyltransferases can recognise their substrates through linear sequence motifs and determination of these motifs is critical to understand methyltransferase mechanism, function and drug targeting. Here we describe MT-MAMS (methyltransferase motif analysis by mass spectrometry), a quantitat...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2018-09-03 | PXD009515 | Pride
Motif Methylation Methyltransferase 
ProteomicsDiscovery of arginine methylation, phosphorylation and their co-occurrence in condensate-associated proteins in Saccharomyces cerevisiae
The formation of condensates in membraneless organelles is thought to be driven by protein phase separation. Arginine methylation and serine/threonine phosphorylation are important in the phase separation process, however these post-translational modifications are often present in intrinsically diso...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-17 | PXD022403 | Pride
Yeast Methylation Phosphorylation Crosstalk 
ProteomicsMechanisms of site-specific methylation by a highly conserved elongation factor 1A lysine methyltransferase
Translation elongation factor 1A (eEF1A) is an essential and highly conserved protein required for protein synthesis in eukaryotes. In both Saccharomyces cerevisiae and human, five different methyltransferase enzymes methylate specific residues on eEF1A, making eEF1A the eukaryotic protein targeted ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2024-01-03 | PXD042599 | Pride
Crosslinking mass spectrometry Protein methyltransferase Protein methylation 
ProteomicsPRMT6 substrate specificity analysis
Protein arginine methyltransferase 6 (PRMT6) catalyses the asymmetric dimethylation of arginines on numerous substrate proteins within the human cell. In particular, PRMT6 methylates histone H3 arginine 2 (H3R2) which affects both gene repression and activation. However, the substrate specificity of...
ORGANISM(S): Homo Sapiens 
PXD016711 | panorama
ProteomicsRPL40 methyltransferase discovery and characterisation
The eukaryotic ribosome is highly modified by protein methylation, yet many of the responsible methyltransferases remain unknown. Here we have identified SMYD5 as a ribosomal protein methyltransferase that catalyses trimethylation of RPL40 at lysine 22. Through a systematic mass spectrometry-based a...
ORGANISM(S): Homo Sapiens 
PXD056489 | panorama
ProteomicsProline-adjacent phosphosites on S. cerevisiae histone demethylase Rph1p are salt stress responsive and important for cell growth in the salt stress response
Phosphorylation of histone lysine demethylases is an important mechanism by which the cell modulates chromatin dynamics to regulate its response to stress. There is evidence that the Saccharomyces cerevisiae H3K36me2/3 demethylase, Rph1p, is an integrator of many signalling events. However, there is...
ORGANISM(S): Saccharomyces Cerevisiae 
2026-02-10 | PXD059939 | panorama
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