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TranscriptomicsConcordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study
Background: Genome-wide transcriptome profiling generated by microarray and RNA-Seq often provides deregulated genes or pathways applicable only to larger cohort. On the other hand, individualized interpretation of transcriptomes is increasely pursued to improve diagnosis, prognosis, and patient tre...
ORGANISM(S): Homo sapiens 
2013-11-20 | E-GEOD-52493 | biostudies-arrayexpress
MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
UnknownSingle-session gamified virtual reality exposure therapy for spider phobia vs. traditional exposure therapy: study protocol for a randomized controlled non-inferiority trial.
Not available
S-EPMC4736108 | biostudies-literature
TranscriptomicsPost-weaning selenium and folate supplementation affects gene and protein expression and global DNA methylation in mice fed high-fat diets
Background: Consumption of high fat diets has negative impacts on health and well-being, some of which may be epigenetically regulated. Selenium and folate are two compounds which influence epigenetic mechanisms. We investigated the hypothesis that post-weaning supplementation with adequate levels o...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-43038 | biostudies-arrayexpress
MetabolomicsRapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report the metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic netwo...
2019-07-13 | MTBLS180 | MetaboLights
TranscriptomicsExpression data from mouse embryonic stem cells across a time course of Erk stimulation
Fgf signaling via Erk activation has been associated with both neural induction and the generation of a primed state for the differentiation of embryonic stem cells (ESCs) to all somatic lineages. To dissect the role of Erk in both ESC self-renewal and lineage specification we explore the requireme...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-59755 | biostudies-arrayexpress
UnknownProfound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis.
Not available
S-EPMC4766010 | biostudies-literature
UnknownDrug treatments for covid-19: living systematic review and network meta-analysis
Not available
S-EPMC7390912 | biostudies-literature
TranscriptomicsTranscriptomic analysis of the zebrafish inner ear points to growth hormone mediated regeneration following acoustic trauma
Transcripts for GH, MHC Class I and II genes, and heavy- and light-chain myosins, as well as many others genes, were differentially regulated in the zebrafish inner ear following overexposure to sound. Following acoustic trauma in the zebrafish inner ear, we used microarray analysis to identify gene...
ORGANISM(S): Danio rerio 
2011-06-02 | E-GEOD-29669 | biostudies-arrayexpress
UnknownRandomized Phase III Noninferiority Study Comparing Two Radiotherapy Fractionation Schedules in Patients With Low-Risk Prostate Cancer.
Not available
S-EPMC4981980 | biostudies-literature
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