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TranscriptomicsActivity of the Bacillus anthracis 20 kDa protective antigen component
Edema factor of anthrax binds to the protective antigen (PA83) which cleaves to PA63 and PA20. The role of PA20 was examined using highthroughput gene expression analysis of human peripheral blood mononuclear cells (PBMC) exposed to PA20. Keywords: Toxicity determination PBMC obtained from differe...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12533 | biostudies-arrayexpress
TranscriptomicsBrain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder
Social stress mouse models were used to simulate human post-traumatic stress disorder (PTSD). C57B/6 mice exposed to SJL aggressor mice exhibited behaviors accepted as PTSD-in-mouse phenotype: 'frozen' motion, aggressor’s barrier avoidance, startled jumping, and retarded locomotion. Transcripts in...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-45035 | biostudies-arrayexpress
TranscriptomicsmiRNA expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study1]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our initial study (Study I) with four experimental conditions where we varied the length of time that subservient mice were exposed to aggr...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52869 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study1]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our initial study (Study I) with four experimental conditions where we varied the length of time that subservient mice were exposed to aggr...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52866 | biostudies-arrayexpress
TranscriptomicsmiRNA expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study2]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our time-course study (Study II) with three experimental conditions where we varied the length of time that subservient mice were exposed t...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52872 | biostudies-arrayexpress
TranscriptomicsImmune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study
Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent environment for opportunistic infection by augmenting virulence and suppressing the host defense. Presumably, extraterrestrial infection ma...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-54213 | biostudies-arrayexpress
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