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TranscriptomicsCleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-{kappa}B Activation
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated ly...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-25527 | biostudies-arrayexpress
UnknownArtificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels.
Not available
S-EPMC9657332 | biostudies-literature
TranscriptomicsKey differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling
Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in fair skinned populations worldwide and its incidence is increasing. Despite previous observations of multiple genetic abnormalities in cSCC, the oncogenic process remains elusive. The purpose of this study was to inve...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-45216 | biostudies-arrayexpress
TranscriptomicsCharacterisation of Anaplastic Large Cell Lymphoma Stem Cells
Anaplastic Large Cell Lymphoma (ALCL) is propagated by cancer stem cells which are identified by their ability to efflux dye and hence reside in the side population (SP) on FACS analysis. In order to understand the origins of these ALCL SP cells we purified SP and main population (MP; SP-depleted) c...
ORGANISM(S): Homo sapiens 
2012-06-24 | E-GEOD-38906 | biostudies-arrayexpress
TranscriptomicsDifferential Expression of NF-kB target genes in MALT lymphoma with and without chromosome translocation
MALT lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harboring such translocation do not respond to H. pylori eradication, while those without translocation can be...
ORGANISM(S): Homo sapiens 
2010-05-31 | E-GEOD-18736 | biostudies-arrayexpress
TranscriptomicsMutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability
K-ras mutations are observed in around 40% human colorectal adenomas and carcinomas and contribute to the pathogenesis of human and rodent colorectal tumour formation. Previously, we developed and characterised a strain of transgenic mice with inducible intestinal epithelial expression of K-rasVal12...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-24010 | biostudies-arrayexpress
TranscriptomicsAn integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma (Main Study)
This SuperSeries is composed of the following subset Series: GSE35424: methylation analysis was carried out on 12 SMZL, 6 MCL and 6 FL cases by the Cambridge group using Illumina Infinium Human Methylation 27 Array GSE35425: Oligo aCGH on 21 SMZL cases were carried out by the Cambridge group using...
ORGANISM(S): Homo sapiens 
2012-08-30 | E-GEOD-21554 | biostudies-arrayexpress
TranscriptomicsIdentification of molecular mechanisms involved in pathogenesis of MALT lymphoma from small sample size
MALT lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harboring such translocation do not respond to H. pylori eradication, while those without translocation can b...
ORGANISM(S): Homo sapiens 
2010-10-07 | E-GEOD-16024 | biostudies-arrayexpress
TranscriptomicsAn integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma (Affymetrix HG-U133plus2 gene expression microarray)
Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, t...
ORGANISM(S): Homo sapiens 
2012-08-30 | E-GEOD-35426 | biostudies-arrayexpress
TranscriptomicsAn integrated genomic and expression analysis of 7q deletion in SMZL (Illumina Infinium Human Methylation 27 array)
Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, t...
ORGANISM(S): Homo sapiens 
2012-08-30 | E-GEOD-35424 | biostudies-arrayexpress
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