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TranscriptomicsTranscription profiling of rat - triazole antifungal toxicogenomics: rat_repro_Liver
The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was ...
ORGANISM(S): Rattus norvegicus 
2008-04-09 | E-GEOD-10411 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat testis exposed TO triazole antifungals TO assed Toxicity
The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was ...
ORGANISM(S): Rattus norvegicus 
2008-04-09 | E-GEOD-10412 | biostudies-arrayexpress
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
TranscriptomicsThe MYC-MIZ1 interaction defines tumor identity
Medulloblastoma (MB) is the most common malignant brain tumor. MB is a cerebellar tumor that occurs mostly in children between the ages of 3-7 years but also in adults. Human MBs are classified into four subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3) and G4, each of which with distinc...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-64425 | biostudies-arrayexpress
UnknownAn expert consensus for the management of chronic hepatitis B in Asian Americans.
Not available
S-EPMC5900913 | biostudies-literature
UnknownComprehensive tissue deconvolution of cell-free DNA by deep learning for disease diagnosis and monitoring.
Not available
S-EPMC10334733 | biostudies-literature
TranscriptomicsTGF-β Tumor Suppression Through A Lethal EMT
TGF-β is a major tumor suppressor in gastrointestinal (GI) and squamous carcinomas, which exhibit frequent genetic inactivation of Smad4, a key TGF-β signaling component. Apoptosis is implicated as an important mediator of the tumor suppressive function of TGF-β, although this process remains poo...
ORGANISM(S): Mus musculus 
2016-02-24 | E-GEOD-72069 | biostudies-arrayexpress
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
UnknownA human model of Batten disease shows role of CLN3 in phagocytosis at the photoreceptor-RPE interface.
Not available
S-EPMC7864947 | biostudies-literature
TranscriptomicsTranscriptomic analysis of the woodchuck model of chronic hepatitis B: Spleen gene expression in uninfected, resolved and chronically infected woodchucks
The Eastern woodchuck (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to the human hepatitis B virus (HBV). The woodchuck is used as an animal model for studying chronic hepatitis B (CHB) and HBV-associated hepatocellular carcinoma (HCC) in ...
ORGANISM(S): Marmota monax 
2012-04-10 | E-GEOD-36544 | biostudies-arrayexpress
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