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TranscriptomicsRibosome profiling of Tunicamycin-treated and -untreated 17Cl1 cells
Ribosome profiling (RiboSeq) analysis of murine 17 clone 1 (17Cl-1) cells with and without Tunicamycin treatment. Tunicamycin is known to induce the unfolded protein response, and the objective of this work was to assess the impact of Tunicamycin on cellular translation. Additionally, we sought to ...
ORGANISM(S): Mus musculus 
2021-11-09 | E-MTAB-5391 | biostudies-arrayexpress
TranscriptomicsAnalysis of coronavirus and infected host-cell gene expression through RNA sequencing and ribosome profiling
Ribosome profiling (RiboSeq) (maps positions of translating ribosomes on the transcriptome) and RNASeq (quantifies the transcriptome) analysis of murine 17 clone 1 (17Cl-1) cells infected with Murine coronavirus strain A59 (MHV-A59). Samples comprise 1 and 8 h mocks, 1, 2.5, 5 and 8 h post infection...
ORGANISM(S): Mus musculus 
2016-02-08 | E-MTAB-4111 | biostudies-arrayexpress
TranscriptomicsHistone deacetylase inhibition replicates aspects of the adaptive response to exercise and improves muscle metabolism and cardiac function in obesity.
Drugs used to treat obesity and type 2 diabetes have limited efficacy in directly normalising muscle metabolism. The discovery of molecules mediating exercise adaptations, and drugs that modulate their activity, is a potential strategy to address this therapeutic gap. Here we show that genetic impai...
ORGANISM(S): Mus musculus 
2015-01-28 | E-GEOD-54642 | biostudies-arrayexpress
ProteomicsA proteomic map of B cell activation and its shaping by mTORC1, MYC and Iron - MYC KO data
Using high resolution quantitative mass spectrometry we have explored how immune activation and the metabolic checkpoint kinase mTORC1 (mammalian target of rapamycin complex 1) regulate the proteome of B lymphocytes. Triggering the B cell receptor, CD40 and the IL-4 receptor induced considerable re-...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-09 | PXD074535 | Pride
Mtorc1 Myc B cells 
UnknownDe novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Not available
S-EPMC7007577 | biostudies-literature
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