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TranscriptomicsshRNAi profiling of human MDA-MB-231 cells expressing anti-p53 (shp53) short-hairpin RNAs treated with TFGbeta or control
TGFβ ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers. The molecular nature of this switch remains enigmatic. We now show that TGFβ-dependent cell migration, invasion and metastasis are empowered by mutant-p...
ORGANISM(S): Homo sapiens 
2009-04-11 | E-GEOD-14491 | biostudies-arrayexpress
ProteomicsRepurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment
The myeloma bone marrow microenvironment drives proliferation of malignant plasma cells and promotes resistance to therapy. Interleukin-6 (IL-6) and downstream JAK/STAT signaling are thought to be central components of these microenvironment-induced phenotypes. In a prior drug repurposing screen, we...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006581 | Pride
Lc-msms Lfq Myeloma Bone marrow microenvironment Tofacitinib Human 
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