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ProteomicsA comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans
DNA damage causes genomic instability underlying many diseases, with traditional analytical approaches providing minimal insight into the spectrum of DNA lesions in vivo. Here we used untargeted chromatography-coupled tandem mass spectrometry-based adductomics (LC-MS/MS) to define the landscape of D...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2023-09-12 | PXD045311 | Pride
Adductomics Strp mrm 
TranscriptomicsBinary cell fate decision as high-dimensional critical state transition
During commitment of a multipotent stem or progenitor cell to a particular lineage, a large number of genes alter their expression in a coordinated manner orchestrated by the gene regulatory network (GRN). The constraints imposed by the GRN govern how cells move in the high-dimensional gene expressi...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-70405 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse carotid bodies from A/J vs.DBA/2J
We hypothesize that gene expression in the CBs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes. More specifically, (1) genes related to CB function are expressed less in the A/J mice compared to DBA/2J mice; (2) gene expression levels of morphogenic an...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5313 | biostudies-arrayexpress
ProteomicsQuantitative profiling of the enzymatic activity of the protein lysine mono-methyltransferase SMYD2 using SILAC-based proteomics
The significance of non-histone lysine methylation in cell biology and human disease is an emerging area of research exploration, and small molecule inhibitors that selectively and potently target “writers” and “erasers” of methyl-lysine, such as the protein lysine mono-methyltransferase SMYD2, are ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080785 | MassIVE
GenomicsAS
WTCCC2 project samples from Ankylosing spondylitis Cohort
EGAD00010000150 | EGA
TranscriptomicsTranscription profiling of Lotus japonicus grown under different salt acclimation regimes
Model legume Lotus japonicus was subjected to non-lethal long-term salinity and profiled at the transcriptomic level. Three independent experiments were performed, testing two experimental designs: a traditional gradual acclimation following a step-wise increase of salt concentration and an initial ...
ORGANISM(S): Lotus japonicus 
2008-07-17 | E-MEXP-1204 | biostudies-arrayexpress
MetabolomicsMetabolomic responses to long-term salt stress in related Lotus species (B)
The legume genus Lotus includes glycophytic forage crops and other species adapted to extreme environments, such as saline soils. Understanding salt tolerance mechanisms will contribute to the discovery of new traits which may enhance the breeding efforts towards improved performance of legumes in m...
2015-09-14 | MTBLS15 | MetaboLights
MetabolomicsMetabolomic responses to long-term salt stress in related Lotus species (C)
The legume genus Lotus includes glycophytic forage crops and other species adapted to extreme environments, such as saline soils. Understanding salt tolerance mechanisms will contribute to the discovery of new traits which may enhance the breeding efforts towards improved performance of legumes in m...
2015-09-14 | MTBLS16 | MetaboLights
MetabolomicsMetabolomic responses to long-term salt stress in related Lotus species (A)
The legume genus Lotus includes glycophytic forage crops and other species adapted to extreme environments, such as saline soils. Understanding salt tolerance mechanisms will contribute to the discovery of new traits which may enhance the breeding efforts towards improved performance of legumes in m...
2015-09-14 | MTBLS14 | MetaboLights
UnknownStepwise asynchronous telehealth assessment of patients with suspected axial spondyloarthritis: results from a pilot study.
Not available
S-EPMC10766678 | biostudies-literature
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