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UnknownActivation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.
Not available
S-EPMC2672886 | biostudies-literature
TranscriptomicsChronic Hypoxia predicts Poor Prognosis in Hepatocellular Carcinoma
Background - Hepatocellular carcinomas (HCCs) are heterogeneous tumors with respect to etiology, cell of origin and biology. The course of the disease is unpredictable and is in part dependent on the tumor microenvironment. One of the microenvironmental factors is hypoxia, which is known to promote ...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-15366 | biostudies-arrayexpress
ProteomicsStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired turnover of damaged mitochondria...
ORGANISM(S): Homo Sapiens 
2026-01-12 | PXD042782 | panorama
UnknownImpact of BCR::ABL1 single nucleotide variants on asciminib efficacy.
Not available
S-EPMC11518997 | biostudies-literature
TranscriptomicsGene expression signatures in motor neuron disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions
Amyotrophic lateral sclerosis and primary lateral sclerosis are two syndromic variants within the motor neurone disease spectrum. Whilst primary lateral sclerosis is associated with loss of upper motor neurons and a more benign disease course up to 17yrs, amyotrophic lateral sclerosis is caused by ...
ORGANISM(S): Homo sapiens 
2014-04-16 | E-GEOD-56808 | biostudies-arrayexpress
TranscriptomicsMutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
Gene expression profiling has been performed on motor cortex and spinal cord homogenates and of sporadic ALS cases and controls, to identify genes and pathways differentially expressed in ALS. More recent studies have combined the use of laser capture microdissection (LCM) with gene expression profi...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-19332 | biostudies-arrayexpress
GenomicsAS
WTCCC2 project samples from Ankylosing spondylitis Cohort
EGAD00010000150 | EGA
GenomicsGenomewide association studies in ankylosing spondylitis
The aim of this study was to identify genes associated with ankylosing spondylitis susceptibility in British and Australian individuals of European descent.
EGAS00000000104 | EGA
GenomicsUC
WTCCC2 project Ulcerative Colitis (UC) samples
EGAD00000000025 | EGA
GenomicsWTCCC2 case-control study for Ulcerative Colitis
WTCCC2 project genome-wide case-control association study for Ulcerative Colitis (UC) using the 1958 British Birth Cohort and the UK National Blood Service collections as controls.
EGAS00000000084 | EGA
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