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GenomicsCU DPMCN Functional Genomics DAC
Data Access Committee EGAC00001001015
EGAC00001001015 | EGA
Genomics273ad39f-3094-4126-a10e-96c1321a07fb - samples
FastQ files with paired-end RNAseq data for human fetal brain homogenate from 120 samples (12-19 post-conception weeks).
EGAD00001004363 | EGA
GenomicsFBSeq: RNA sequencing of human fetal brain.
RNA sequencing of 120 human fetal brains (aged 12-19 post-conception weeks) was performed as part of a Medical Research Council (U.K.) funded project (MR/L010674/2) to investigate genetic effects on gene expression in the developing human brain and their role in neuropsychiatric disorders. Human fet...
EGAS00001003214 | EGA
TranscriptomicsMethylomic trajectories across human
Dynamic changes to the epigenome mediate key neurobiological and cognitive processes in the central nervous system, and also play a role in transcriptional regulation during brain development. Although the importance of DNA methylation in brain development is highlighted by the neurodevelopmental de...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-58885 | biostudies-arrayexpress
TranscriptomicsMethylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.
Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describ...
ORGANISM(S): Homo sapiens 
2014-09-13 | E-GEOD-61380 | biostudies-arrayexpress
TranscriptomicsCortical hypermethylation across an extended region spanning the HOXA gene cluster on chromosome 7 is robustly associated with Alzheimer's disease neuropathology
Alzheimer's disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. We undertook an epigenome-wide association study across three independent brain tissue cohorts (total n = 999) to identify differential DNA methylation associated with neuropatholo...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-80970 | biostudies-arrayexpress
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