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MetabolomicsLung Lipidomic Alterations in Beagle Dogs Infected with Toxocara canis

Toxocariasis, mainly caused by Toxocara canis, and to a lesser extent, Toxocara cati, is a neglected parasitic zoonosis. The mechanisms that underlie the changes in lipid metabolism of T. canis infection in Beagle dogs' lungs remain unclear. Lipidomics is a rapidly emer...

2023-08-21 | MTBLS5583 | MetaboLights
ProteomicsDomain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating its tumor suppressive functions, and by conferring aberrant pro-carcinogenic activities. We report here that mis-sense mutants in the p53 DNA-binding domain (DBD) and the transactivation domain (TAD) unexpectedly activate...
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD031725 | JPOST Repository
UnknownAltered Gut Microbiota in H1-Antihistamine-Resistant Chronic Spontaneous Urticaria Associates With Systemic Inflammation.
Not available
S-EPMC8967245 | biostudies-literature
MetabolomicsLipidomic Changes in the Liver of Beagle Dogs Associated with Toxocara canis Infection

In this study, lipid alterations in Beagle dog’s liver caused by Toxocara canis infection were investigated by using liquid chromatography with tandem mass spectrometry at 12 hours post infection (hpi), 24 hpi and 36 days post infection (dpi). A total of 6 categories and 42 subclasses of...

2022-08-30 | MTBLS4015 | MetaboLights
UnknownPhosphorylation of shiftless is important for inhibiting the programmed -1 ribosomal frameshift.
Not available
S-EPMC12716391 | biostudies-literature
UnknownDesign, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR.
Not available
S-EPMC4027470 | biostudies-literature
UnknownA Machine Learning-Based Preclinical Osteoporosis Screening Tool (POST): Model Development and Validation Study.
Not available
S-EPMC10686208 | biostudies-literature
UnknownPredictive model of acute kidney injury after spontaneous intracerebral hemorrhage: A multicenter retrospective study.
Not available
S-EPMC10472951 | biostudies-literature
UnknownThe inhibition of YTHDF3/m<sup>6</sup>A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer.
Not available
S-EPMC10797697 | biostudies-literature
TranscriptomicsExpression data from dark-grown AtGATA2 (At2g45050) overexpression transgenic line, homozygous bri1-116 and Col-0 wild type
Molecular genetic analyses support important roles for the AtGATA2 gene in brassinolide (BR) and light regulation of plant development. The overexpression line 6-9 of AtGATA2 suppresses the etiolated phenotype of Col-0 grown in the dark. Using microarray analysis, we identified genes differentially ...
ORGANISM(S): Arabidopsis thaliana 
2011-11-09 | E-GEOD-25396 | biostudies-arrayexpress
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