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TranscriptomicsTranscription profiling of human SK-MEL-2 melanoma cell line transfected with E2F-1 and doxorubicin or transfected with a LacZ control plus doxorubicin to investigate the molecular mechanisms of a combination of E2F-1 gene therapy and chemotherapy.
SK-MEL-2 cells treated with Ad-E2F-1 (MOI 2), Ad-E2F-1 (MOI 2)plus doxorubicin 0.1uM, or Ad-LacZ (MOI 2) plus doxorubicin 0.1uM. The combination of E2F-1 gene therapy and chemotherapy produces a synergistic effect on melanoma cell apoptosis. However, the molecular mechanisms have not been fully eluc...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2715 | biostudies-arrayexpress
TranscriptomicsExpression data from normal melanocyte, melanoma cells and their exosomes
This SuperSeries is composed of the following subset Series: GSE35387: Expression data from normal melanocyte, melanoma cells and their exosomes (microRNA) GSE35388: Expression data from normal melanocyte, melanoma cells and their exosomes (mRNA) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-10-10 | E-GEOD-35389 | biostudies-arrayexpress
TranscriptomicsExpression data from normal melanocyte, melanoma cells and their exosomes (mRNA)
Exosomes are small membraneous vesicles secreted into body fluids by tumors. Tumor exosomes contain intact and functional mRNAs, small RNAs (including miRNAs), and proteins that can alter the cellular environment to favor tumor growth. Further exploration into the molecular profiling of exosomes may...
ORGANISM(S): Homo sapiens 
2012-10-10 | E-GEOD-35388 | biostudies-arrayexpress
TranscriptomicsExpression data from normal melanocyte, melanoma cells and their exosomes (microRNA)
Exosomes are small membraneous vesicles secreted into body fluids by tumors. Tumor exosomes contain intact and functional mRNAs, small RNAs (including miRNAs), and proteins that can alter the cellular environment to favor tumor growth. Further exploration into the molecular profiling of exosomes may...
ORGANISM(S): Homo sapiens 
2012-10-10 | E-GEOD-35387 | biostudies-arrayexpress
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