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UnknownQingfei Zhisou oral liquid alleviates fever-induced inflammation by regulating arachidonic acid and lysophospholipids metabolism and inhibiting hypothalamus transient receptor potential ion channels expression.

Objective

To explore how Qingfei Zhisou oral liquid (, QFZS) adjusts body temperature bias and the interaction of inflammatory factors levels and metabolomic differences.

Methods

Dry yeast was subcutaneously injected at 10 mL/kg to establish the pyrexia model. We randomly divided 60 S...
S-EPMC11462524 | biostudies-literature
UnknownIdentification of a novel WAS mutation and the non-splicing effect of a second-site mutation in a Chinese pedigree with Wiskott-Aldrich syndrome.

Background

Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency disorder caused by abnormal expression of the WAS protein (WASp) due to mutations in the WAS gene, and is generally characterized by microthrombocytopenia, eczema, recurrent infections, and high susceptibility to a...
S-EPMC9783790 | biostudies-literature
UnknownA New Criterion for Pediatric AKI Based on the Reference Change Value of Serum Creatinine.

Background

Current definitions of AKI do not take into account serum creatinine's high variability in children.

Methods

We analyzed data from 156,075 hospitalized children with at least two creatinine tests within 30 days. We estimated reference change value (RCV) of creatinine on the...
S-EPMC6115652 | biostudies-literature
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