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ProteomicsTargeting TNK2 reverses the immunosuppressive tumor microenvironment and synergizes with immunochemotherapy in pancreatic cancer
In this study, we utilized spatial transcriptome analysis, genomic copy number variation mutation profiling, and single-cell sequencing to identify an abnormal overexpression of TNK2, which is inversely correlated with PDAC prognosis and the development of an immune-suppressive microenvironment. Pre...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-11 | PXD055503 | Pride
Immunosuppressive tumor microenvironment Immunotherapy resistance Pancreatic ductal adenocarcinoma Tnk2 
ProteomicsHAT1-meidated phosphoproteomics liver tissues
Phosphoproteomics in liver tissues of WT and Hat1-/-mice
ORGANISM(S): Mus Musculus 
PXD043633 |
ProteomicsSILAC-based quantitative mass spectrometry analysis of RPA1-containing protein complex
SILAC-based quantitative mass spectrometry analysis of RPA1-containing protein complex
ORGANISM(S): Homo Sapiens 
PXD028105 |
ProteomicsIdentification of ADAR1 associated proteins
To understand how ADAR1 controls genome stability, affinity purification and mass spectrometry were employed to identify the interactomes of ADAR1 with cellular extracts from HeLa cells stably expressing FLAG-ADAR1.Mass spectrometry analysis of FLAG-ADAR1 associated proteins. The differential protei...
ORGANISM(S): Homo Sapiens 
2022-11-15 | PXD038167 |
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