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UnknownThe Plasticizer Bisphenol A Perturbs the Hepatic Epigenome: A Systems Level Analysis of the miRNome.
Not available
S-EPMC5664119 | biostudies-literature
TranscriptomicsA gp130-induced Src/Yes-YAP Cascade Links Inflammation to Regeneration in the Mammalian Intestine
gp130Act cDNA was PCR-amplified and inserted into a plasmid containing the 12.4-kb Villin promoter. The 15.7-kb expression cassette was excised by PmeI digestion, purified, and injected into fertilized C57BL/6 oocytes to obtain founder mice, two of which transmitted the gp130Act transgene. Small int...
ORGANISM(S): Mus musculus 
2015-02-21 | E-MTAB-2400 | biostudies-arrayexpress
TranscriptomicsGene expression data in the retina in HIV positive and HIV negative eyes
To examine the gene expression data in the retina in HIV positive and HIV negative autopsy eyes we used a microarray approach with the HumanHT-12 v4 Expression BeadChip.



Retinal punches were made for the following regions



CWS = cotton wool spot

IRH = intra-retina...
ORGANISM(S): Homo sapiens 
2013-09-20 | E-MEXP-3757 | biostudies-arrayexpress
TranscriptomicsSerine protease-mediated wounding identifies localized epidermal wound response genes in Drosophila melanogaster
We have used trypsin-mediated wounding to amplify the transcriptional response to clean puncture wounding. We studied the transcriptional response of clean puncture wounding and trypsin puncture wounding in relation to unwounded wild-type late-stage embryos. Trypsin puncture wounding generally incr...
ORGANISM(S): Drosophila melanogaster 
2013-08-12 | E-MEXP-3755 | biostudies-arrayexpress
TranscriptomicsAmplification of WHSC1L1 regulates expression and estrogen independent activation of ERα in SUM 44 cells and is associated with ERα over-expression in breast cancer
Estrogen receptor positive breast cancer is the most prevalent form of breast cancer. Although a number of available drugs are highly effective at blocking estrogen mediated receptor activity, thousands of patients die every year from ER positive breast cancers because the disease progresses to a st...
ORGANISM(S): Homo sapiens 
2016-05-07 | E-MTAB-3739 | biostudies-arrayexpress
TranscriptomicsRole of CCR2+ myeloid cells in pancreatic β cell growth and regeneration
Pancreas and spleen were microdissected from wild type (C57B6/SV129 background) E14.5 embryos and P0 newborn pups. Pools of 30-60 tissues were used. Tissues were digested for 1 hour at 37°C in HBSS/0.1% collagenase A/20 µg/ml DNase I, followed by dissociation of the cell clusters into single cells...
ORGANISM(S): Mus musculus 
2017-12-06 | E-MTAB-5427 | biostudies-arrayexpress
TranscriptomicsThe long non-coding HOTAIR is modulated by cyclic stretch and WNT/beta-CATENIN in human aortic valve cells and is a novel repressor of calcification genes
Aortic valve calcification is a significant and serious clinical problem for which there are no effective medical treatments. Individuals born with bicuspid aortic valves, 1-2% of the population, are at the highest risk of developing aortic valve calcification. Aortic valve calcification involves in...
ORGANISM(S): Homo sapiens 
2014-05-02 | E-MTAB-2409 | biostudies-arrayexpress
TranscriptomicsBiological effects of marine contaminated sediments on Sparus aurata juveniles
Chemical analysis of the compounds present in sediment, although informative, often is not indicative of the downstream biological effects that these contaminants exert on resident aquatic organisms. More direct molecular methods are needed to determine if marine life is affected by exposure to sedi...
ORGANISM(S): Sparus aurata 
2011-01-01 | E-TABM-1146 | biostudies-arrayexpress
TranscriptomicsInfluence of NSD3 and ESR1 knockdown on gene expression in SUM-44 cells
Total RNA was isolated from SUM-44 cells subjected to 5 days of puromycin selection following infection with lentiviral shRNA constructs against NSD3-S or ESR1 as well as LacZ control. Samples were harvested in triplicate and prepared and sequenced simultaneously.
ORGANISM(S): Homo sapiens 
2018-09-01 | E-MTAB-5823 | biostudies-arrayexpress
TranscriptomicsDevelopmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes_TS
The objective of this study was to investigate the effects of rosiglitazone (Avandia) on gene expression in neonatal rat ventricular myocytes. Myocytes were exposed to rosiglitazone ex vivo. The two factors examined in the experiment were drug exposure (r
ORGANISM(S): Rattus norvegicus 
2015-02-21 | E-MTAB-2426 | biostudies-arrayexpress
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