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TranscriptomicsGene expression profiles after knockdown of Nardilysin in TMK-1 gastric cancer cells
Nardilysin (NRDc), a metalloendopeptidase of the M16 family, has been reported to promote the ectodomain shedding and resulting activation of various growth factors and cytokines, but its role in cancer biology have not been elucidated. Microarray experiments were performed to analyze the chnages of...
ORGANISM(S): Homo sapiens 
2011-05-16 | E-GEOD-29144 | biostudies-arrayexpress
TranscriptomicsEmergence of a developmental stage-dependent human liver disease signature demonstrated by directed differentiation of alpha-1 antitrypsin deficient iPS cells [HumanMethylation450]
We monitored 9 pluripotent stem cell lines across three time points of hepatic directed differentiation, representing 3 developmental stages: undifferentiated (T0), definitive endoderm (T5), and early hepatocyte (T24). ESCs (n=3) and patient-derived normal (n=3) or PiZZ (n=3) iPSCs were analyzed in ...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-66077 | biostudies-arrayexpress
TranscriptomicsGene profile of PTIP deletion in adult murine cardiac tissue
Methylation of histone H3 lysine 4 (H3K4me) at actively expressed, cell type-specific genes is established during development by the Trithorax group of epigenetic regulators. In mammals, the Trithorax family includes KMT2A-D (MLL1-4), a family of SET domain proteins that function in large complexes...
ORGANISM(S): Mus musculus 
2010-03-06 | E-GEOD-20570 | biostudies-arrayexpress
TranscriptomicsEmergence of a developmental stage-dependent human liver disease signature demonstrated by directed differentiation of alpha-1 antitrypsin deficient iPS cells [miRNA-2_0]
We monitored 9 pluripotent stem cell lines across three time points of hepatic directed differentiation, representing 3 developmental stages: undifferentiated (T0), definitive endoderm (T5), and early hepatocyte (T24). ESCs (n=3) and patient-derived normal (n=3) or PiZZ (n=3) iPSCs were analyzed in ...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-66075 | biostudies-arrayexpress
TranscriptomicsEmergence of a developmental stage-dependent human liver disease signature demonstrated by directed differentiation of alpha-1 antitrypsin deficient iPS cells [HuGene-1_0-st]
We monitored 9 pluripotent stem cell lines across three time points of hepatic directed differentiation, representing 3 developmental stages: undifferentiated (T0), definitive endoderm (T5), and early hepatocyte (T24). ESCs (n=3) and patient-derived normal (n=3) or PiZZ (n=3) iPSCs were analyzed in ...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-66076 | biostudies-arrayexpress
TranscriptomicsGene expression profile of isolated splenic NK cells from mice treated with ptaquiloside and/or selenium
To better understand the immunosuppressor mechanism of ptaquiloside in splenic NK cells and the reversion of this effect by selenium, we have employed whole genome microarray expression profile to identify genes associated with immunosuppression. Among 89 genes induced by ptaquiloside treatment in s...
ORGANISM(S): Mus musculus 
2013-07-24 | E-GEOD-30629 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for latent and clinical tuberculosis (TB)
For further identify the differentiation between latent and clinical tuberculosis (TB), we employed whole genome microarray expression profiling to study genes with significant expression change in peripheral CD4+T cells between healthy control, latent tuberculosis (LTB) and clinical tuberculosis (T...
ORGANISM(S): Homo sapiens 
2012-08-06 | E-GEOD-27882 | biostudies-arrayexpress
TranscriptomicsMutant PI3K cooperates with HER2 to promote mammary tumor formation and induces trastuzumab resistance in vivo
HER2 (ERBB2) gene amplification and PIK3CA mutations often co-occur in breast cancer, and aberrant activation of the PI3K pathway has been implicated in resistance to HER2-directed therapies. We have created a mouse model of HER2-overexpressing (HER2+), PIK3CAH1047R-mutant breast cancer. Mice expres...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-41118 | biostudies-arrayexpress
TranscriptomicsInfluence of cell permeable Tre-recombinase (CPTR) treatment on T-cell gene expression
CEM-ss cells were treated with or without a recombinantly expressed recombinase and gene expression profiles were compared. Two-condition experiment, Untreated CEM-ss vs. CPTR treated CEM-ss cells
ORGANISM(S): Homo sapiens 
2012-02-22 | E-GEOD-32643 | biostudies-arrayexpress
TranscriptomicsIGR_U985_CLL_EGR2_GE_STUDY_OB
Chronic lymphocytic leukemia (CLL), the most frequent adult leukemia in western countries, is a clonal accumulation of mature B-lymphocytes and its natural history is yet unclear. By using sequencing and cellular biology approaches on a cohort of CLL patient samples, we show here that acquired CLL m...
ORGANISM(S): Mus musculus 
2014-06-18 | E-MTAB-1764 | biostudies-arrayexpress
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