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TranscriptomicsRegulation of the Mycobacterium tuberculosishypoxic response gene encoding alpha-crystallin
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-05 | E-GEOD-8639 | biostudies-arrayexpress
TranscriptomicsInhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program
An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-21 | E-GEOD-8839 | biostudies-arrayexpress
UnknownSafety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study.
Not available
S-EPMC5493052 | biostudies-literature
TranscriptomicsDefined hypoxic model timecourse of H37Rv and H37Rv:deltadosR
Background: A significant body of evidence accumulated over the last century suggests a link between hypoxic microenvironments within the infected host and the latent phase of tuberculosis. Studies to test this correlation have identified the M. tuberculosis initial hypoxic response, controlled by ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-02-20 | E-GEOD-9331 | biostudies-arrayexpress
UnknownA new method for predicting survival in stage I non-small cell lung cancer patients: nomogram based on macrophage immunoscore, TNM stage and lymphocyte-to-monocyte ratio.
Not available
S-EPMC7210133 | biostudies-literature
TranscriptomicsMycobacterium tuberculosis H37Rv transcriptional response to antibacterial agents
Bacteria commonly adapt to stresses by altering gene expression. To understand the response of M. tuberculosis (MTB) to various antibacterial agents, we performed transcriptomics on MTB bacilli exposed to several test compounds as well as known drugs (capreomycin, cycloserine, ethionamide, isoniazi...
ORGANISM(S): Mycobacterium tuberculosis 
2015-11-11 | E-GEOD-71200 | biostudies-arrayexpress
UnknownPhase I/Ib study of olaparib and carboplatin in women with triple negative breast cancer.
Not available
S-EPMC5668030 | biostudies-literature
UnknownAcquired <i>RAD51C</i> Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma.
Not available
S-EPMC12593227 | biostudies-literature
UnknownSecondary Somatic Mutations Restoring <i>RAD51C</i> and <i>RAD51D</i> Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.
Not available
S-EPMC5612362 | biostudies-literature
UnknownImpact of Complete Revascularization in the ISCHEMIA Trial.
Not available
S-EPMC10529674 | biostudies-literature
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