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UnknownAn ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis.
Not available
S-EPMC6603039 | biostudies-literature
TranscriptomicsThe cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54743 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rat strains stimulated with myelin oligodendrocyte glycoprotein (MOG) to identify the alternative splicing.
Experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rats were immunized with myelin oligodendrocyte glycoprotein (MOG) to induce an autoimmune response.
Seven days later draining inguinal lymph nodes were removed. 2 conditions were examined: 'ex vivo' and 'MOG res...
ORGANISM(S): Rattus norvegicus 
2009-11-01 | E-MEXP-2237 | biostudies-arrayexpress
TranscriptomicsGenome-wide replication analysis of a yeast eco1 mutant by deep sequencing.
Eco1 is the acetyltransferase that establishes sister-chromatid cohesion during DNA replication. Budding yeast with an eco1 mutation that genocopies Roberts syndrome displaysreduced ribosomal DNA (rDNA) transcription and a transcriptional signature of starvation. Weshow that deleting FOB1, a gene en...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54742 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis comparing yeast Eco1 mutant W216G to mutants of FOB1 and RAD61
Eco1 is an acetyltransferase subunit of the cohesin complex and acts during DNA replication to establish cohesion between sister chromatids. However, cohesin has additional functions in gene expression, DNA damage repair, and higher-order organization of chromosomes. The eco1 mutant W216G disrupts a...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54741 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling in the Lungs of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer
COPD is a common and disabling lung disease for which very few therapeutic options are currently available. We reasoned that global gene expression profiling of COPD lungs could reveal previously unidentified disease pathways for potential therapeutic interventions. Forty-eight human lung samples we...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8500 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of generic impact of protein aggregation (aggregation of proteins not associated with neurodegenerative disease) on gene expression in human cultured cells
In this study the generic impact of protein aggregation (aggregation of proteins not associated with neurodegenerative disease) on gene expression in cultured cells was investigated by DNA microarray technology. The survey of gene expression showed that the Hsp40, Hsp70 and Hsp105 genes, all of whic...
ORGANISM(S): Homo sapiens 
2005-07-20 | E-MEXP-389 | biostudies-arrayexpress
UnknownHistone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma.
Not available
S-EPMC12705669 | biostudies-literature
TranscriptomicsTranscription profiling of immortalised human mammary luminal epithelial cells and variants expressing a moderate and high level of ERBB2
To investigate changes in gene expression associated with ERBB2, expression profiling of immortalised human mammary luminal epithelial cells and variants expressing a moderate and high level of ERBB2 has been carried out using cDNA microarrays corresponding to approximately 6,000 unique genes/ESTs. ...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-SNGR-8 | biostudies-arrayexpress
UnknownDevelopment and validation of a targeted gene sequencing panel for application to disparate cancers.
Not available
S-EPMC6864073 | biostudies-literature
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