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TranscriptomicsAnalysis of gene expression in JAK2 exon 12-mutant erythroblasts
For 13 patients with JAK2 exon 12-mutated polycythemia vera (PV), we compared genome-wide RNA profiles of JAK2-mutant (mutant) and wild-type erythroid colonies, grown from a single patient in the same culture plate. This paired approach controls for factors including age, gender, treatment, germline...
ORGANISM(S): Homo sapiens 
2015-10-04 | E-MTAB-3946 | biostudies-arrayexpress
ProteomicsParacrine Signaling in Visceral Fat
Accumulation of visceral (VIS) as opposed to subcutaneous (SUB) fat is a predictor of metabolic disorders, insulin resistance, and cardiovascular disease. This is due in part to the limited capacity of VIS fat to buffer lipids allowing them to deposit in insulin-sensitive tissues, thus impairing ins...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD014672 | Pride
Paracrine signaling Mouse Visceral fat 
UnknownSingle-cell analysis identifies CRLF2 rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia.
Not available
S-EPMC6398588 | biostudies-literature
ProteomicsThe long noncoding RNA Caren protects against heart failure via suppressing the Hint1-ATM signaling pathway
Long noncoding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiac disease, but their function in heart failure (HF) is not yet fully understood. Using a gene trapping approach in mouse embryonic stem cells, we identified a novel cytoplasmic lncRNA, dubbed Caren (cardiomyocyte-enri...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-08 | PXD016186 | Pride
Mouse Heart failure Lncrna 
UnknownHydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.
Not available
S-EPMC6269131 | biostudies-literature
UnknownBrain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration.
Not available
S-EPMC9976981 | biostudies-literature
UnknownFavorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study.
Not available
S-EPMC8478641 | biostudies-literature
UnknownIntragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?
Not available
S-EPMC5728462 | biostudies-literature
TranscriptomicsMinotaur is critical for primary piRNA biogenesis [RNA-Seq]
Piwi proteins and their associated small RNAs are essential for fertility in animals. This is due, in part, to their roles in guarding germ cell genomes against the activity of mobile genetic elements. piRNA populations direct Piwi proteins to silence transposon targets and as such form a molecula...
ORGANISM(S): Drosophila melanogaster 
2013-04-27 | E-GEOD-46423 | biostudies-arrayexpress
TranscriptomicsMutation Order Affects Tumor Evolution and Clinical Course of Disease
Background: Cancers result from accumulation of somatic mutations and their properties are thought to reflect the sum of these mutations. However, little is known about the consequences of altering the order of mutation acquisition. Methods: Mutation order was determined in myeloproliferative neopl...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-MTAB-3086 | biostudies-arrayexpress
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