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GenomicsEstablishment of regions of genomic activity during the Drosophila maternal-to-zygotic transition
A conspicuous feature of early animal development is the lack of transcription from the embryonic genome, and it typically takes several hours to several days (depending on the species) until widespread transcription of the embryonic genome begins. Although this transition is ubiquitous, relatively ...
ORGANISM(S): Drosophila melanogaster 
2014-10-16 | E-GEOD-58935 | biostudies-arrayexpress
UnknownRegulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase.
Not available
S-EPMC7318740 | biostudies-literature
TranscriptomicsMouse Marginal Zone B-cell with/without Tfh RNASeq data analysis
Mouse Marginal Zone B-cell with/without Tfh
ORGANISM(S): Mus musculus 
2024-01-24 | E-MTAB-11677 | biostudies-arrayexpress
TranscriptomicsEpithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine
Microarray of sort-purified WT and Il18r1-/- Foxp3+ Treg cells from colonic lamina propria during prevention of naive CD4+ T cell mediated intestinal inflammation.
ORGANISM(S): Mus musculus 
2014-12-31 | E-MTAB-3067 | biostudies-arrayexpress
TranscriptomicsVirR and RevR regulate many Clostridium perfringens genes in a reciprocal manner
We further characterize the VirSR and RevR regulatory networks by profiling the C. perfringens strain JIR325 and its isogenic virR and revR regulatory mutants using strand-specific RNA-seq. Two independent biological replicates were sequenced for each strain, generating more than 90 million sequence...
ORGANISM(S): Clostridium perfringens 
2016-08-03 | E-GEOD-72137 | biostudies-arrayexpress
TranscriptomicsDeregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in BCP-ALL
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia We report two novel, cryptic chromosomal abnormalities in precursor B-cell acute lymphoblastic leukemia (BCP-ALL): a translocation, either t(X;14)(p22;q32)...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17165 | biostudies-arrayexpress
UnknownDurability of ChAdOx1 nCoV-19 vaccination in people living with HIV.
Not available
S-EPMC9057612 | biostudies-literature
TranscriptomicsInnate immune pathways in afferent lymph following vaccination with poly(I:C) -containing liposomes
Many modern vaccines use defined adjuvants to stimulate the innate immune system and shape the adaptive immune response. The exact nature of these innate signals and whether immune differentiation can originate within the periphery is not known. In the present study we used an ovine lymphatic cannul...
ORGANISM(S): Ovis aries 
2013-08-01 | E-GEOD-38533 | biostudies-arrayexpress
TranscriptomicsDifferential expression between Sh2b3 knockout and wild type mice
To validate the predicted Sh2b3 derived gene regulatory subnetwork using integrative network approach in human population study, we examined the gene expression levels of whole blood in WT (wild-type) and Sh2b3-/- mice by RNA sequencing, and identified the differentially expressed genes. RNA sequen...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-65348 | biostudies-arrayexpress
UnknownLymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.
Not available
S-EPMC4362266 | biostudies-literature
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