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TranscriptomicsDifferential virulence gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus infection
Although dermatophytes are the most common agents of superficial mycoses in humans and animals, the molecular basis of the pathogenicity of these fungi is largely unknown. In vitro digestion of keratin by dermatophytes is associated with the secretion of multiple proteases, which are assumed to be r...
ORGANISM(S): Arthroderma benhamiae 
2010-03-04 | E-GEOD-15873 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins
Dermatophytes are highly specialized filamentous fungi which cause the majority of superficial mycoses in humans and animals. The high secreted proteolytic activity of these microorganisms during growth on proteins is assumed to be linked with their particular ability to exclusively infect keratiniz...
ORGANISM(S): Trichophyton rubrum 
2008-12-30 | E-GEOD-11711 | biostudies-arrayexpress
TranscriptomicsIdentification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans
The identification of novel transcription factors associated to antifungal response may allow the discovery of fungal specific targets for new therapeutic strategies. A collection of 241 C. albicans transcriptional regulators mutants was screened for altered susceptibility to fluconazole, caspofungi...
ORGANISM(S): Candida albicans 
2012-05-02 | E-GEOD-37682 | biostudies-arrayexpress
TranscriptomicsComprehensive analysis of Arabidopsis expression level polymorphisms with simple inheritance
Expression level polymorphisms (ELPs) often result in cis-acting expression quantitative trait loci (cis-eQTL), which are important QTL and association mapping tools and account significantly for phenotypic variability. Generally, it is assumed that such stably heritable ELP represent regulatory ele...
ORGANISM(S): Arabidopsis thaliana 
2010-05-16 | E-GEOD-13628 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Mus musculus 
2016-02-15 | E-GEOD-51012 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Danio rerio 
2016-02-18 | E-GEOD-51013 | biostudies-arrayexpress
TranscriptomicsImpact of normalization on Agilent miRNA microarray expression profiling
Profiling miRNA levels in cells with miRNA-microarrays is becoming a widely used technique. Although normalization methods for mRNA gene expression arrays are well established, miRNA array normalization has so far not been investigated in detail. In this study we investigate the impact of normalizat...
ORGANISM(S): Homo sapiens 
2009-02-16 | E-GEOD-12085 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Danio rerio 
2016-02-18 | E-GEOD-51018 | biostudies-arrayexpress
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