Differential virulence gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus infection

ABSTRACT: Although dermatophytes are the most common agents of superficial mycoses in humans and animals, the molecular basis of the pathogenicity of these fungi is largely unknown. In vitro digestion of keratin by dermatophytes is associated with the secretion of multiple proteases, which are assumed to be responsible for their particular specialization to colonize and degrade keratinized host structures during infection. To address this hypothesis a guinea pig infection model was established for the zoophilic dermatophyte Arthroderma benhamiae which causes highly inflammatory cutaneous infections in humans and rodents. Microarray analysis revealed a distinct in vivo protease gene expression profile in the fungal cells, which is surprisingly different from the pattern elicited during in vitro growt

ORGANISM(S): Arthroderma benhamiae

SUBMITTER: Michel Monod 

PROVIDER: E-GEOD-15873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress