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TranscriptomicsTranscription profiling of mouse skin carcinogenesis in FVB/N and Tg.Ac mice
Female FVB/N and Tg.Ac (hemizygotes) mice 3-5 weeks of age were purchased from Harlan UK and Taconic UK, respectively. The mice were contained in an isolator and maintained at 19C with 50% relative humidity and a 12-hour light-dark cycle. Following a 1 week acclimatisation period the dorsal skin o...
ORGANISM(S): Mus musculus 
2005-10-01 | E-MEXP-188 | biostudies-arrayexpress
TranscriptomicsModeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer [RNA-Seq]
Estrogen receptor-α (ERα) is an important driver of breast cancer and is the target for hormonal therapies, anti-estrogens and drugs that limit estrogen biosynthesis (aromatase inhibitors). Mutations in the ESR1 gene identified in metastatic breast cancer provide a potential mechanism for acquired...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78285 | biostudies-arrayexpress
TranscriptomicsExpression data for UPEC and GBS cystitis in female C57BL/6 mice
Data defines for the first time a whole bladder transcriptome of UPEC cystitis in female C57BL/6 mice using genome-wide expression profiling and temporal analysis to map early host response pathways stemming from UPEC colonization We used microarrays to detail the global programme of gene expression...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-27575 | biostudies-arrayexpress
TranscriptomicsVinyl Chloride Degradation by Mixed Microbial Community KB1
A shotgun metagenome microarray was created and used to investigate gene transcription during vinyl chloride (VC) dechlorination by a microbial enrichment culture called KB1. The array was constructed by spotting genomic fragments amplified from short-insert libraries of KB1 metagenomic DNA. Subse...
ORGANISM(S): dechlorinating enrichment culture KB-1 
2010-01-26 | E-GEOD-20041 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the maturing erythroblast
Understanding the pattern of gene expression and identifying the specific genes expressed during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here we have isolated four distinct populations of erythroblasts at successive erythropoietin-dependent stages of erythropoie...
ORGANISM(S): Homo sapiens 
2011-03-02 | E-GEOD-22552 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of small RNAs in Heliconius melpomene
Background: Heliconius butterflies are an excellent model system for studies of adaptive convergent and divergent phenotypic traits. Wing colour patterns are used as signals to both predators and potential mates and are inherited in a Mendelian manner. The underlying genetic mechanisms of pattern fo...
ORGANISM(S): Heliconius melpomene melpomene 
2011-06-02 | E-GEOD-23292 | biostudies-arrayexpress
TranscriptomicsComprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities.
Cells resembling bone marrow mesenchymal stem cells (MSC) have been isolated from many organs but their functional relationships have not been thoroughly examined. Here we compared the immunophenotype, gene expression, multipotency and immunosuppressive potential of MSC-like colony-forming cells fro...
ORGANISM(S): Mus musculus 
2011-08-30 | E-GEOD-31738 | biostudies-arrayexpress
UnknownEnhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.
Not available
S-EPMC11629703 | biostudies-literature
UnknownThe effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.
Not available
S-EPMC3145073 | biostudies-literature
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