Sort   by:  
 Page size 
TranscriptomicsWhole genome expression array profiling highlights differences in mucosal defense genes in Barrett's esophagus and esophageal adenocarcinoma.
Esophageal adenocarcinoma (EAC) has become a major concern in Western countries due to rapid rises in incidence coupled with very poor survival rates. One of the key risk factors for the development of this cancer is the presence of Barrett’s esophagus (BE), which is believed to form in response to ...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-28302 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 5 human parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubicin
Title: Analysis of gene expression changes involved in the development of acquired drug resistance.
Description: In vitro model of drug resistance consisting of 5 parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubic...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-MIMR-11 | biostudies-arrayexpress
TranscriptomicsPathways leading to phosphorylation of p450c17 and to the post-translational regulation of androgen biosynthesis
Cytochrome P450c17 (P450c17) is the single enzyme that catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities and hence is the crucial decision-making step that determines the class of steroid made in a steroidogenic cell. Although both activities are catalyzed on a single active site, the...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44311 | biostudies-arrayexpress
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila to investigate the nodal points and complexity of Notch-Ras signal integration
Metazoans utilize a handful of highly conserved signaling pathways to create a signaling backbone that governs all stages of development, by providing spatial and temporal cues that influence gene expression. How these few signals have such a versatile developmental action is of significance to evol...
ORGANISM(S): Drosophila melanogaster 
2009-01-14 | E-GEOD-11203 | biostudies-arrayexpress
TranscriptomicsThe effects of UVB and the organic osmolyte betaine on rat epidermal keratinocytes in an organotypic culture system
Betaine (trimethylglycine) is a non-toxic, highly water-soluble organic osmolyte widely used in skin care due to its assumed moisturizing and protective properties, but only few studies have addressed its specific effects in skin. Here, the cellular and molecular targets of betaine were analyzed by ...
ORGANISM(S): Rattus norvegicus 
2015-10-26 | E-GEOD-63004 | biostudies-arrayexpress
TranscriptomicsBidirectional manipulation of SF-1 (NR5A1) in NCI-H295R cells
SF-1 (NR5A1) was overexpressed (Over) or knocked down with shRNA (shRNA) in NCI-H295R human adrenocortical tumor cells and differential global gene expression analysed 48 hours later using Affymetrix GeneChip Human Gene 1.0ST arrays. Over: 5 million cells were transfected (Amaxa Nucleofection) with ...
ORGANISM(S): Homo sapiens 
2011-01-11 | E-GEOD-26529 | biostudies-arrayexpress
TranscriptomicsAutocrine IL-1α mediates NF-κB activation by oncogenic ras in keratinocytes
Constitutively active RAS plays a central role in the development of skin cancer in the classical two stage skin carcinogenesis in mice and in a number of human cancers. Ras-mediated tumor formation is commonly associated with upregulation of cytokines and chemokines that mediate an inflammatory res...
ORGANISM(S): Mus musculus 
2011-08-28 | E-GEOD-22777 | biostudies-arrayexpress
TranscriptomicsProfiling of growth and differentiation factor 15 regulated genes in hepatoma cells
To systematically profile the GDF15-regulated genes in hepatoma cells and to elucidate the possible role of GDF15 on biological processes, high-density oligonucleotide microarrays were hybridized with samples prepared from GDF15- or PBS-treated Huh7.5.1 cells. We found that a total of 894 genes were...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-25397 | biostudies-arrayexpress
TranscriptomicsWnt ligands from the embryonic surface ectoderm regulate bimetallic strip optic cup morphogenesis in the mouse
Wnt signaling in early eye development, specifically the lens placode shows expression of 12 out of 19 Wnt ligands. We these Wnt activities were suppressed using conditional deletion of Wntless, dramatic phenotypic changes in morphogensis occurred. Microarray analysis of the genes that were changed...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-65154 | biostudies-arrayexpress
Sort   by:  
 Page size