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TranscriptomicsDifferential gene expression in mouse kidney following 72 hours of colistin exposure by Illumina WG-6_V2 array
Colistin sulfate (polymixin E) is an antibiotic prescribed with resurging frequency for multidrug resistant gram negative bacterial infections. It is associated with nephrotoxicity in humans in up to 33% of cases. Little is known regarding genes involved in colistin nephrotoxicity. A murine model o...
ORGANISM(S): Mus musculus 
2013-11-05 | E-GEOD-46410 | biostudies-arrayexpress
TranscriptomicsHepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS) [mRNA]
Perfluorooctanesulfonate (PFOS) has been widely used in a variety of industrial and commercial applications as a surfactant and stain repellent. PFOS causes liver damage (including liver tumors) in experimental animals, primarily via interaction with PPARa and CAR/PXR. We investigated the involvemen...
ORGANISM(S): Rattus norvegicus 
2015-08-01 | E-GEOD-69520 | biostudies-arrayexpress
GenomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64516 | biostudies-arrayexpress
TranscriptomicsHeLa cell response to overexpression of wild type and mutated forms of the P19 splice variant of c-H-ras
The c-H-ras proto-oncogene undergoes alternative splicing of the exon termed IDX giving rise to a novel protein of the Ras family, p19 (H-RasIDX). The experiment tests the effect on the transcriptome of overexpressing the wild type and W164A mutated forms of p19. Keywords: genetic modification Thre...
ORGANISM(S): Homo sapiens 
2009-12-29 | E-GEOD-12059 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility [NimbleGen]
Environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of adult onset disease, including testis disease and male infertility. The current study was designed to determine the impact of an altered sperm epigenome on the subsequent development of an adult somatic...
ORGANISM(S): Rattus norvegicus 
2014-07-07 | E-GEOD-59109 | biostudies-arrayexpress
TranscriptomicsStriatum from rats treated with methamphetamine
Comparison of striatum from rats treated with either saline or 40mg/kg methamphetamine Keywords: other
ORGANISM(S): Rattus norvegicus 
2004-09-30 | E-GEOD-1711 | biostudies-arrayexpress
TranscriptomicsEvaluating Gene Expression in C57BL/6J and DBA/2J Mouse Striatum Using RNA-Seq and Microarray
C57BL/6J (B6) and DBA/2J (D2) are two of the most commonly used inbred mouse strains in neuroscience research. However, the only currently available mouse genome is based entirely on the B6 strain sequence. Subsequently, oligonucleotide microarray probes are based solely on this B6 reference sequenc...
ORGANISM(S): Mus musculus 
2011-04-12 | E-GEOD-26024 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-22775 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Mus musculus 
2010-07-21 | E-GEOD-22773 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Mus musculus 
2010-07-22 | E-GEOD-22774 | biostudies-arrayexpress
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