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TranscriptomicsSmoking is Associated with Shortened Airway Cilia
Background: Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length. Based on models of mucociliary clearance predicting cilia length must exceed th...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-16696 | biostudies-arrayexpress
TranscriptomicsMicroarrays reveal oocyte lipid storage droplet gene as key factor in reproductive dysfunction of captive-reared P. monodon
Background: Aquaculture of the black tiger prawn Penaeus monodon remains severely constrained by an almost total dependence on wild-caught broodstock. Reliance on wild-caught broodstock stems, for the most part, from reduced reproductive potential of captive-reared females. Reproductive performance ...
ORGANISM(S): Penaeus monodon 
2011-09-01 | E-GEOD-31862 | biostudies-arrayexpress
TranscriptomicsAn integrated global analysis of compartmentalized HRAS signaling
Modern omics technologies allow us obtaining global information on different types of biological networks. However, integrating these different types of analyzes into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that ...
ORGANISM(S): Homo sapiens 
2019-03-12 | E-MTAB-7672 | biostudies-arrayexpress
TranscriptomicsThe Role of Macrophages in the Development of Human Renal Allograft Fibrosis in the First Year after Transplantation
The aim of this study was to investigate the role of infiltrating macrophages in renal allograft fibrosis. Forty-six protocol renal allograft biopsies obtained one-year after transplantation were stained with Sirius Red to quantify fibrosis and double stained with CD68 and CD206 to identify the prop...
ORGANISM(S): Homo sapiens 
2015-01-28 | E-GEOD-65326 | biostudies-arrayexpress
MetabolomicsStrain level differences in marine microbial parasite-host metabolites and host mortality dynamics

Parasitism is a widespread source of mortality among marine microbial communities, with members of the diverse alveolate group Syndiniales being most prevalent and frequently identified in global omics studies. Despite their ubiquity, not much is known about Syndiniales parasite-host infection dy...

2026-10-05 | MTBLS11219 | MetaboLights
TranscriptomicsCoxiella burnetii, the agent of Q fever, persists in adipocytes
Coxiella burnetii, the agent of Q fever, persists in humans despite specific immune responses: however, its reservoir remains unknown. We detected C. burnetii in adipose tissue from BALB/c and C57/BL6 mice 4 months after infection when no bacteria were found in other tissues. C. burnetii infected cu...
ORGANISM(S): Mus musculus 
2014-05-25 | E-GEOD-46335 | biostudies-arrayexpress
TranscriptomicsGene expression profile of murine Flvcr-deleted and control CD4+CD8+ double-positive (DP) thymocytes
Genomewide microaarray analysis of murine DP thymocytes to determine the genes whose expression was altered by FLVCR loss Gene signatures from Flvcr+/+ DP thymocytes was compared to gene signatures from Flvcr-/- DP thymocytes Total RNA obtained from sort-purified Flvcr-/- and Flvcr+/+ DP thymocytes
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-50202 | biostudies-arrayexpress
TranscriptomicsMultifaceted maturation of monocyte-derived dendritic cells stimulated by intracellular bacteria
Background: It has been shown that intracellular pathogens hijack DC functions to evade immune defense mechanisms. In this study, we investigated the responses of human monocyte derived DCs to four intracellular bacteria, Tropheryma whipplei, Coxiella burnetii, Brucella abortus and Orientia tsutsuga...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-49016 | biostudies-arrayexpress
TranscriptomicsPromyelocytic cells response to Anaplasma phagocytophilum infection
Gene expression profiling of human promyelocytic cells in response to infection with Anaplasma phagocytophilum. Total RNA derived from 3DPI Anaplasma phagocytophilum-infected HL-60 cells was labeled with A647 and total RNA derived from 3DPI Mock-infected HL-60 cells was labeled with A546. For each...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-1694 | biostudies-arrayexpress
TranscriptomicsGene Expression in Human Lung Type II Cells
Normal lung function relies on mature function of alveolar type II cels, which have numerous functions including to regulate ion and fluid flux, produce immune molecules, and synthesize and secrete surfactant to stabilize air spaces. Differentiation of type II cells from precursor epithelial cells ...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-19699 | biostudies-arrayexpress
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