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UnknownData integration workflow for search of disease driving genes and genetic variants.
Not available
S-EPMC3075259 | biostudies-literature
TranscriptomicsDisrupted interaction of transmembrane prostatic acid phosphatase and snapin will lead to prostate cancer
Disrupted interaction of transmembrane prostatic acid phosphatase and snapin will lead to prostate cancer
ORGANISM(S): Mus musculus 
2013-09-12 | E-MTAB-1191 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hela CD4+ cells transfected with epitope tagged eTat or parental vector to identify therapeutic targets for HIV-1 infection in the host proteome.
Despite the success of Highly Active Anti-Retroviral Therapy (HAART), patients often stop treatment due to the inception of side effects. Furthermore, viral resistance often develops, making one or more of the drugs ineffective. Identification of novel targets for therapy that may not develop resist...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6431 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mammary epithelial cells with MycER activation using 4-hydroxytamoxifen following growth in 2D monoloyers with or without EGF and insulin or in 3D Matrigel culture
MCF10A MycER cells were grown either on 2D monolayer culture in the presence of complete growth medium, in the absence of EGF and insulin or in 3D Matrigel culture for 20 days to form acinar structures. MycER was activated with 4-hydroxytamoxifen (4-OHT) in all samples for 2 or 48 h. Control cells w...
ORGANISM(S): Homo sapiens 
2006-12-31 | E-MEXP-765 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of submandibular salivary glands from PAP knockout and wild type mice
Prostatic acid phosphatase is the main acid phosphatase in mouse submandibular salivary gland
ORGANISM(S): Mus musculus 
2014-04-15 | E-MTAB-2099 | biostudies-arrayexpress
ProteomicsDectin-1/Syk pathway activates autophagy-dependent unconventional protein secretion from human macrophages
Before stimulation, the cells were washed and the culture media was changed to RPMI-1640. After stimulation, cell culture media were collected, concentrated, and the proteins were precipitated with 2-D Clean-Up Kit (GE Healthcare) followed by protein alkylation, trypsin digestion and iTRAQ labellin...
ORGANISM(S): Homo sapiens (Human) 
2014-05-12 | PXD000574 | Pride
Human Macrophages Dectin-1 Itraq 
UnknownA synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells.
Not available
S-EPMC11114247 | biostudies-literature
GenomicsTissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs. [ChIP-Seq]
We report the in vivo androgen receptor (AR) binding sites in murine prostate, epididymis and kidney in response to physiological androgen testosterone using ChIP-sequencing and gene expression profiling by microarray. From AR cistrome analysis, we identified tissue-specific collaborating factors i....
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-47192 | biostudies-arrayexpress
TranscriptomicsFoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells (mRNA)
We report the androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell lines, LNCaP-1F5 and VCaP in response to physiological androgen 5a-dihydrotestosterone (DHT) using ChIP-sequencing. We compare the AR recruitment by DHT to that by partial agonist/antagonist cypr...
ORGANISM(S): Homo sapiens 
2013-02-05 | E-GEOD-39654 | biostudies-arrayexpress
UnknownPOIBM: batch correction of heterogeneous RNA-seq datasets through latent sample matching.
Not available
S-EPMC9048693 | biostudies-literature
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