Sort   by:  
 Page size 
MetabolomicsEngineered Oncolytic VSV Enhances Tumor Killing in HBV-Positive HCC
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, with chronic hepatitis B virus (HBV) infection being a major contributor to its development. Despite this, effective treatment for HBV-associated HCC remains a significant challenge. In this study, we combined the s...
2025-07-17 | MTBLS12196 | MetaboLights
ProteomicsHuh-7 exosomes and HBV
Hepatitis B virus (HBV) infection could cause hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV-mediated pathogenesis is only partially understood, but X protein (HBx) reportedly possesses oncogenic potential. Exosomes are small membrane vesicles with diverse functions released by various...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080794 | MassIVE
ProteomicsPhosphoproteome profiling unravels rewiring of chromatin organization factors in host cells upon HBV infection
Hepatitis B virus (HBV) infection leads tdevelopment of fatal liver complications. Due to a lack of effective measure to cure HBV infection, complete eradication of HBV is difficult. Thus, novel HBV therapeutic strategies are needed. Host proteins involved in the HBV infection processes are known to...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD015393 | Pride
Hbv host response Mass spectrometry Hepatitis b virus Phosphoproteome Chromatin remodelling 
ProteomicsUncover proteins binding HBV rcDNA
To comprehensively uncover host proteins involved in HBV rcDNA repair, we employed a rcDNA repair system, which can simulate the process of cccDNA formation in vitro. Biotinylated rcDNA first bonds with streptavidin magnetic beads and is then incubated with cell extracts of HepG2-NTCP-K7 cells to fa...
ORGANISM(S): Homo sapiens (Human) 
2024-12-18 | PXD053940 | Pride
Hbv rcdna Dna repair Hepatocytes 
ProteomicsLabel-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line
Hepatitis B virus (HBV) infection is a major health problem worldwide. Recent evidence suggests that various viruses can manipulate the infection process by secretion of specific viral and cellular components into exosomes, small nanometer-sized (30-150 nm) vesicles secreted from various cells. Howe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080718 | MassIVE
TranscriptomicsHBV Infection and DNA Stimulation Induce a Unique Innate Immune Response in Hepatocytes
Background and Aims: Recent identification of intracellular DNA sensing pathways and involvement in numerous diverse disease processes including viral pathogenesis and autoimmunity suggests a role for these processes in liver pathology. The presence of these pathways in the liver and their role in H...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-69590 | biostudies-arrayexpress
TranscriptomicsLiver Regeneration Gene Signature in Hepatitis B virus (HBV)-Associated Acute Liver Failure Identified by Gene Expression Profiling
The liver has inherent regenerative capacity via mitotic division of mature hepatocytes. However, if the hepatic loss is massive or mature hepatocyte proliferation is impaired by chronic liver injury, HSPC are activated to support liver regeneration. Access to liver tissue from 4 patients who underw...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-38941 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP6.0 array data for different clinical outcomes of HBV infection
Chronic hepatitis B virus (HBV) infection is a serious global public health problem. To identify susceptibility loci for disease progression of HBV infection, we performed this genome-wide association study using DNA pools of case and control constructed by progressed HBV carriers (acute liver failu...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-26034 | biostudies-arrayexpress
TranscriptomicsB-Cell Gene Signature with Massive Intrahepatic Production of Antibodies to Hepatitis B Core Antigen in HBV-Associated Acute Liver Failure
Hepatitis B virus (HBV)-associated acute liver failure (ALF) is a dramatic clinical syndrome due to a sudden loss of hepatic cells leading to multiorgan failure. The mechanisms whereby HBV induces ALF are unknown. We used gene expression profiling to establish a molecular definition of hepatitis B v...
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-14668 | biostudies-arrayexpress
ProteomicsComprehensive proteomics identification of IFN-λ3-regulated anti-viral proteins in HBV-transfected cells
Hepatitis B virus (HBV) causes both acute and chronic liver inflammation. Approximately 600,000 CHB patients each year die of HBV-related diseases such as cirrhosis and liver cancer. Therefore, CHB remains a global health concern. Although there have been anti-HBV agents for treating CHB, they have ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-17 | PXD007896 | Pride
Hepatitis b virus Ifn-λ3 Dimethyl labeling Lc-ms/ms 
Sort   by:  
 Page size