Sort   by:  
 Page size 
MetabolomicsEngineered Oncolytic VSV Enhances Tumor Killing in HBV-Positive HCC
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, with chronic hepatitis B virus (HBV) infection being a major contributor to its development. Despite this, effective treatment for HBV-associated HCC remains a significant challenge. In this study, we combined the s...
2025-07-17 | MTBLS12196 | MetaboLights
ProteomicsGeneration and utilization of a monoclonal antibody against hepatitis B virus core protein for a comprehensive interactome analysis
Hepatitis B virus (HBV) core antigen (HBc) is a structural protein that forms the viral nucleocapsid and is involved in various steps of the viral replication cycle, but its role in the pathogenesis of HBV infection is still elusive. In this study, we generated a mouse monoclonal antibody against HB...
ORGANISM(S): Homo Sapiens (human) 
2023-02-21 | PXD036961 | JPOST Repository
ProteomicsPRMT5: a Novel Regulator of Hepatitis B Virus Replication and an Arginine Methylase of HBV Core
In the study, we identified protein arginine methyltransferase 5 (PRMT5) as a novel restriction factor of HBV replication. We have also demonstrated that PRMT5 can interact with the HBV core and methylate its arginine residues within arginine-rich domain. We identified two types of HBc post-translat...
ORGANISM(S): Homo sapiens (Human) Hepatitis B virus 
2017-11-01 | PXD006828 | Pride
Ubiquitination Hepatitis b virus Arginine methylation Phosphorylation Hbv core protein 
ProteomicsProtein mass Protein mass spectrometry was used to detect the degree of biotinylation of V5-APEX2-HBC-NES after adding H2O2, and to search for host factors that interact with HBV core protein.spectrometry was used to detect the degree of biotinylation of V5-APEX2-HBC-NES after adding H2O2, and to search for host factors that interact with HBV core protein.
Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and liver cancer, representing a global health problem for which a functional cure is difficult to achieve. The HBV core protein (HBc) is essential for multiple steps in the viral life cycle; it is the building block of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD036510 | Pride
Lc-ms/ms hbv hbc apex2 
GenomicsNEDD4-binding protein 1 suppresses HBV replication by regulating HBV RNAs
NEDD4-binding protein 1 suppresses HBV replication by regulating HBV RNAs
PRJNA935255 | ENA
GenomicsSelective depletion of HBV-infected hepatocytes by class A capsid assembly modulators require high levels of intrahepatic HBV core protein
Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators require high levels of intrahepatic HBV core protein
PRJNA1084747 | ENA
GenomicsClass A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation
Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation
PRJNA1033639 | ENA
TranscriptomicsClass A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation
Treatment with hepatitis B virus (HBV) capsid assembly modulators that induce the formation of aberrant HBV core protein structures (CAM-A) leads to programmed cell death, apoptosis, of HBV-infected hepatocytes and subsequent reduction of HBV antigens, which differentiates CAM-A from other CAMs. The...
ORGANISM(S): Mus musculus 
2024-01-23 | GSE246563 | GEO
TranscriptomicsGene expression profiles of NIH3T3 cells stably transfected with the plasmids encoding the wild type PreS/S gene or the nonsense mutant gene (sW182*) of HBV.
Background and Aims: Whether hepatitis B virus (HBV) could play a direct role in hepatocarcinogenesis remains uncertain. The 3' end nonsense mutations of HBV PreS/S gene have been found to encode transcriptional transactivation activity, suggesting these mutations may contribute to HBV-associated on...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-50180 | biostudies-arrayexpress
ProteomicsIdentification of cellular protein interacting with HBV genome by protein mass spectrometry
: Hepatitis B virus (HBV) remains a major public health threat with more than 296 million people chronically infected worldwide at high risk to develop hepatocellular carcinoma. Current therapies are effective in suppressing HBV replication but rarely lead to cure. The fundamental limitation rests o...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD042733 | Pride
Hbv cccdna Mini-chromosome Transcription Therapy 
Sort   by:  
 Page size