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ProteomicsPhosphoproteome profiling unravels rewiring of chromatin organization factors in host cells upon HBV infection
Hepatitis B virus (HBV) infection leads tdevelopment of fatal liver complications. Due to a lack of effective measure to cure HBV infection, complete eradication of HBV is difficult. Thus, novel HBV therapeutic strategies are needed. Host proteins involved in the HBV infection processes are known to...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD015393 | Pride
Hbv host response Mass spectrometry Hepatitis b virus Phosphoproteome Chromatin remodelling 
TranscriptomicsHBV Infection and DNA Stimulation Induce a Unique Innate Immune Response in Hepatocytes
Background and Aims: Recent identification of intracellular DNA sensing pathways and involvement in numerous diverse disease processes including viral pathogenesis and autoimmunity suggests a role for these processes in liver pathology. The presence of these pathways in the liver and their role in H...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-69590 | biostudies-arrayexpress
TranscriptomicsB-Cell Gene Signature with Massive Intrahepatic Production of Antibodies to Hepatitis B Core Antigen in HBV-Associated Acute Liver Failure
Hepatitis B virus (HBV)-associated acute liver failure (ALF) is a dramatic clinical syndrome due to a sudden loss of hepatic cells leading to multiorgan failure. The mechanisms whereby HBV induces ALF are unknown. We used gene expression profiling to establish a molecular definition of hepatitis B v...
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-14668 | biostudies-arrayexpress
TranscriptomicsRole of Humoral Immunity against Hepatitis B Virus Core Antigen in the Pathogenesis of Acute Liver Failure
To investigate the role of viral and host factors in acute liver failure, we analyzed serum and multiple liver specimens obtained at the time of liver transplantation from four well-characterized patients. We carried out an integrated clinicopathological analysis, gene and microRNA expression profil...
ORGANISM(S): Homo sapiens 
2018-10-29 | E-GEOD-96851 | biostudies-arrayexpress
GenomicsSENP3-mediated host defense response contains HBV replication and restores protein synthesis
SENP3-mediated host defense response contains HBV replication and restores protein synthesis
PRJNA505306 | ENA
MetabolomicsMetabolic characterization of the natural progression of chronic hepatitis B (Lipid assays)
Background: Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases. The confinement of HBV replication to the liver, which also acts as the central hub for metabolic and nutritional regulation, e...
2016-06-06 | MTBLS279 | MetaboLights
TranscriptomicsTranscriptome profiles of Huh7.5.1-NTCP cells treated with HBV preS1 peptide
Chronic hepatitis B, C and D virus (HBV, HCV, HDV) infections are leading causes of liver disease and cancer worldwide. Although these viruses differ markedly in their life cycle and genomic organization, they exclusively infect hepatocytes. Recently, the sodium taurocholate cotransporting polypepti...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-79089 | biostudies-arrayexpress
OtherSENP3-mediated host defense response contains HBV replication and restores protein synthesis
Certain organs are capable of containing the replication of various types of viruses. In the liver, infection of Hepatitis B virus (HBV), the etiological factor of Hepatitis B and hepatocellular carcinoma (HCC), often remains asymptomatic and leads to a chronic carrier state. Here we investigated ho...
ORGANISM(S): Homo sapiens 
2018-11-14 | GSE122461 | GEO
TranscriptomicsIdentification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B
The woodchuck model of hepatitis B virus (HBV) infection displays many characteristics of human infection and has particular value for characterizing the host immune responses during the development of chronic infection. Using the newly developed custom woodchuck microarray platform, we compared the...
ORGANISM(S): Marmota monax 
2012-09-22 | E-GEOD-37683 | biostudies-arrayexpress
UnknownThe host gene <i>CSTF2</i> regulates HBV replication via HBV PRE-induced nuclear export.
Not available
S-EPMC11986456 | biostudies-literature
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