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ProteomicsHDAC11 Deacetylates BRAF to Regulate Kinase Activity and Cell Proliferation
Histone acetylation, governed by histone deacetylase (HDAC) enzymes, plays a pivotal role in cell biology. Elevated HDAC expression is linked to poor prognosis in various diseases, including cancer, making HDAC inhibitors clinically valuable. Among the 11 metal-dependent HDAC isoforms, the exception...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD066596 | Pride
Proteomics Braf Substrate profiling Kinase activity Histone deacetylase Hdac11 
TranscriptomicsLoss of HDAC11 leads to reduced secretion of MCP-1 and less severe EAE
HDAC11 regulates IL-10 expression and overexpression of HDAC11 in antigen presenting cells (APCs) leads to a pro-inflammatory phenotype. Conversely, loss of HDAC11 leads to upregulation of IL-10 and immune tolerance. HDAC11 overexpression is also associated with inflammatory diseases including multi...
ORGANISM(S): Mus musculus 
2014-03-31 | E-GEOD-56366 | biostudies-arrayexpress
GenomicsTranscriptomic analysis of day 1 (D1) differentiating WT and HDAC11-deficient mouse myoblasts
Transcriptomic analysis of day 1 (D1) differentiating WT and HDAC11-deficient mouse myoblasts
PRJNA614530 | ENA
UnknownGarcinol Is an HDAC11 Inhibitor.
Not available
S-EPMC7857146 | biostudies-literature
TranscriptomicsLoss of HDAC11 leads to reduced secretion of MCP-1 and less severe EAE
HDAC11 regulates IL-10 expression and overexpression of HDAC11 in antigen presenting cells (APCs) leads to a pro-inflammatory phenotype. Conversely, loss of HDAC11 leads to upregulation of IL-10 and immune tolerance. HDAC11 overexpression is also associated with inflammatory diseases including multi...
ORGANISM(S): Mus musculus 
2014-03-31 | GSE56366 | GEO
UnknownProgramming and Regulation of Metabolic Homeostasis by HDAC11.
Not available
S-EPMC6085537 | biostudies-literature
GenomicsHdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast differentiation by inhibiting Parkin-dependent mitophagy
Hdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast differentiation by inhibiting Parkin-dependent mitophagy
PRJNA1293366 | ENA
TranscriptomicsHdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast differentiation by inhibiting Parkin-dependent mitophagy
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which macrophages play a central role in driving fibrogenesis. In this study, we observed marked upregulation of histone deacetylase 11 (Hdac11) in lung tissues from IPF patients, lung organoid models, and bleomycin‑in...
ORGANISM(S): Mus musculus 
2026-02-27 | GSE303021 | GEO
TranscriptomicsTranscriptomic analysis of day 1 (D1) differentiating WT and HDAC11-deficient mouse myoblasts
To get insight into the transcriptomic changes caused by HDAC11 loss at early myogenic differentiation, we performed RNA sequencing (RNA-Seq) in 24 h differentiated primary myoblasts from WT and HDAC11-deficient mice. Satellite cell-derived primary myoblasts were obtained after FACS isolation of ske...
ORGANISM(S): Mus musculus 
2020-07-10 | GSE147423 | GEO
UnknownHDAC11 deficiency regulates age-related muscle decline and sarcopenia.
Not available
S-EPMC12397452 | biostudies-literature
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