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ProteomicsHydrogen Deuterium Exchange of PDK1
This project consisted of three HDX-MS experiments. First, we compared the dimeric PDK1(SKD-PIF) to monomeric PDK1(SKD) and mapped the differences in deuterium incorporation onto the dimer model. We then compared the deuterium incorporation kinetics for the kinase (PDK1(SKD)) and PH (PDK1(PH) domain...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027401 | Pride
Hdx-ms pdk1 hdx 
ProteomicsStructure of autoinhibited Akt1 reveals mechanism of PIP 3 -mediated activation
To directly observe the conformational changes in Akt1 3P elicited by PIP 3 binding, we performed HDX-MS analysis of Akt1 3P in the presence of plasma membrane-mimicking liposomes (20% cholesterol, 30% phosphatidylcholine, 15% phosphatidylserine, 35% phosphatidylethanolamine) that contained either 0...
ORGANISM(S): Homo sapiens (Human) 
2021-09-01 | PXD022061 | Pride
Pip3 Akt Lipids Hdx-ms 
UnknownElucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonance.
Not available
S-EPMC4295793 | biostudies-literature
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