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Sepsis-associated acute lung injury (SALI) is a life-threatening pulmonary complication triggered by sepsis, which carries a notably high mortality rate. We constructed a rat model of SALI and administered Xuanbai Chengqi Decoction (XCD) as treatment, after which untargeted serum metabolomics ana...

2026-09-29 | MTBLS15292 | MetaboLights
Active DNA demethylation in mammals involves TET-mediated oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxycytosine (5caC). However, genome-wide detection of 5fC at single-base resolution remains challenging. Here we present a bisulfite-free ...
ORGANISM(S): Mus musculus 
In order to identify the molecular mechanism leading to the increase of TRMT6/61A complex in aged HSCs, we purified proteins interacting with TRMT6 and TRMT61A via affinity purification. HEK293T cells stably expressing SFB-tagged TRMT6 or SFB-TRMT61A were lysed in NETN buffer (20 mM Tris-HCl [pH 8.0...
ORGANISM(S): Homo Sapiens 
2023-11-30 | PXD047430 |
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