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MetabolomicsSulfadiazine Sodium Improves Dysfunctional Metabolomics in Toxoplasma gondii-infected Mice
Toxoplasma gondii is an obligate intracellular protozoan parasite that poses a severe threat to human health, especially those immune-compromised individuals. Sulfadiazine sodium (SDZ) is widely used for the treatment of human toxoplasmosis. However, systems biology researches on the therapeutic eff...
2019-06-18 | MTBLS852 | MetaboLights
UnknownRemote ischemic conditioning combined with intravenous thrombolysis for acute ischemic stroke.
Not available
S-EPMC7318096 | biostudies-literature
ProteomicsNeutralization mechanism of a HipA-like toxin targeting isoleucyl-tRNA synthetase
HipAB is a type II toxin-antitoxin (TA) system that targets and inactivates specific aminoacyl-tRNA synthetases in response to various stresses. While the molecular targets and neutralization mechanisms of several HipAB-like TA systems have been well characterized, their structural and functional di...
ORGANISM(S): Escherichia Coli K-12 
PXD062828 |
TranscriptomicsGSK8814: a chemical probe fort he ATAD2 bromodomain
Differential gene expression analysis of LNCaP cells treated with GSK8814 and GSK8815 Total RNA obtained from cells treated with GSK8814 and GSK8815 for 24 hours
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-78868 | biostudies-arrayexpress
MetabolomicsSerum Metabolic Profiling of Oocyst-Induced Toxoplasma gondii Acute and Chronic Infections in Mice Using Mass-Spectrometry
Toxoplasma gondii is an obligate intracellular parasite causing severe diseases in immunocompromised individuals and congenitally infected neonates, such as encephalitis and chorioretinitis. This study aimed to determine whether serum metabolic profiling can (i) identify metabolites associated with ...
2018-04-16 | MTBLS418 | MetaboLights
MetabolomicsMetabolomic signature of mouse cerebral cortex following Toxoplasma gondii infection

BACKGROUND: The protozoan parasite Toxoplasma gondii infects and alters the neurotransmission in cerebral cortex and other brain regions, leading to neurobehavioral and neuropathologic changes in humans and animals. However, the molecules that contribute to these changes remain l...

2020-04-23 | MTBLS770 | MetaboLights
ModelsWang2009 - PI3K Ras Crosstalk
This model is from the article: PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk. Wang CC, Cirit M, Haugh JM Mol. Syst. Biol. 2009;5:246. 19225459 , A...
2024-09-02 | BIOMD0000000288 | BioModels
UnknownAn optimised promoter and signal peptide improves methionine production of a genetically engineered <i>Candida utilis</i> harboring the <i>δ-zein</i> gene.
Not available
S-EPMC12271212 | biostudies-literature
ProteomicsGlobal Proteome in Litopenaeus vannamei
The Pacific white shrimp (Litopenaeus vannamei), one of the most widely cultured shrimp species in the world, usually suffered from chilling stress in China. In order to reveal inner proteomics mechanism of chilling tolerance, we conducted a proteomic analysis on two contrasting shrimp cultivars, na...
ORGANISM(S): Litopenaeus Vannamei 
2018-05-25 | PXD009889 |
ProteomicsCleavable Photo-Crosslinker Enables sFFP-Driven Strategy for Mapping HSP90β Oligomer Structure
Crosslinking technology is a pivotal tool for resolving dynamic protein interaction networks. While traditional chemical crosslinkers face limitations in sensitivity, reaction kinetics, and in situ activation, cleavable and photo-crosslinkers have emerged as alternatives. However, their complex spec...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2026-04-09 | PXD064219 | Pride
Photo-cross-link Hsp90 Randomforest Cleavable cross-linker 
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