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ProteomicsHuman HNF1A KI mice liver proteome analysis
Nonalcoholic fatty liver disease (NAFLD) is a pathological condition caused by excessive fat accumulation in liver. HNF1A is the pathogenic cause of hepatocellular adenoma and HCC. It is an important transcription factor in liver. We constructed a knock-in mice expressing a human dominant negative H...
ORGANISM(S): Mus Musculus 
2023-03-02 | PXD040561 |
ProteomicsRegion and cell-type resolved multi-omic altas of the heart
This work presented the panoramic heart proteome map, and served as the rich resource for heart researches in the future.
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus 
2025-02-17 | PXD060863 |
ProteomicsProteogenomic Characterization of Skull-base Chordoma
Skull-base chordoma (SBC) is a rare, aggressive bone cancer with a high recurrent rate. Genomic studies of SBC have improved our understanding of the disease’s biology. However, the molecular biological characteristics and the effective therapy of SBC remain unknown. Here, we carried out an integrat...
ORGANISM(S): Homo Sapiens 
2024-07-01 | PXD053550 |
ProteomicsIntegrated Plasma and Vegetation Proteomic Characterization of Infective Endocarditis for Early Diagnosis and Treatment
Infective endocarditis, a life-threatening condition, poses significant challenges for early diagnosis and personalized treatment due to insufficient biomarkers and limited understanding of its pathophysiology. Here, we analyzed plasma and vegetation proteomes from 238 patients with infective endoca...
ORGANISM(S): Homo Sapiens 
2025-04-06 | PXD062668 |
ProteomicsIntegrated Proteogenomic Characterization across Major Histological Types of Pituitary Neuroendocrine Tumors
Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker discovery, the causative molecular mechanisms are far from being fully defined. Therefore, more studies are needed to imp...
ORGANISM(S): Homo Sapiens 
2022-10-17 | PXD031467 |
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