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UnknownLigamentous injury-induced ankle instability causing posttraumatic osteoarthritis in a mouse model.
Not available
S-EPMC8905815 | biostudies-literature
UnknownThe Mechanism of Anti-PD-L1 Antibody Efficacy against PD-L1-Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic Effector.
Not available
S-EPMC7253691 | biostudies-literature
UnknownYTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells.
Not available
S-EPMC10150872 | biostudies-literature
UnknownConstruction of self-driving anti-αFR CAR-engineered NK cells based on IFN-γ and TNF-α synergistically induced high expression of CXCL10.
Not available
S-EPMC11489333 | biostudies-literature
ProteomicsHypoxia Regulates Overall mRNA Homeostasis by Inducing Met1-linked Linear Ubiquitination of AGO2 in Cancer Cells
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear. Here we show that hypoxia inhibits global-mRNA dec...
ORGANISM(S): Homo Sapiens 
2021-04-06 | PXD021722 |
ProteomicsThe BPAN disease protein WDR45 forms condensates with Caprin-1 to regulate stress granule disassembly
Beta-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder primarily caused by mutations in the WD repeat domain 45 (WDR45) gene. While WDR45 has traditionally been linked to autophagy, our study uncovers a previously unrecognized role for WDR45 as a cri...
ORGANISM(S): Homo Sapiens 
PXD062911 |
ProteomicsQuantitative proteomics profilling of p62 droplet
Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlying mechanisms are still not fully understood. Mass spectrometry-based proteomics revealed significant enrichment of vesicle trafficking components within p62 bodies.
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2023-06-09 | PXD038262 |
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