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Purpose: Pericytes, the mural cells of blood microvessels, have come into focus as regulators of microvascular development and function, but due to paucity of defining markers, the identification and functional characterization of PC remain problematic, and reported data are often controversial. Her...
ORGANISM(S): Mus musculus 
Little is known about the pan-microvascular transcriptome, particularly considering gene transcripts and their encoded proteins that can be considered as vascular-selective in their expression. Using a combination of publicly available and our own transcript profiles, we identified a core set of gen...
ORGANISM(S): Mus musculus 
Glomerular podocyte cells are critical for the function of the renal ultrafiltration barrier. The highly specialized cell-cell junction of podocytes, the slit diaphragm, has a central role in the filtration barrier. Dendrin is a poorly characterized cytosolic component of the slit diaphragm in where...
ORGANISM(S): Mus musculus 
Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRα. Analysis of Pdgfc null mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy with other PDGFRα ligands might hide additional ...
ORGANISM(S): Mus musculus 
To characterize the vascular proteome of the brain, proteins were extracted from the brain microvascular fragments isolated from adult mice using CD31-coated magnetic beads. The proteins were enzymatically digested and subjected to mass spectrometric analysis
ORGANISM(S): Mus Musculus (mouse) 
The pathogenic mechanisms of common kidney glomerular diseases, including the vast majority of cases of proteinuria, remain unknown. To gain insight into the pathogenesis of proteinuria development, we characterized the glomerular gene expression changes that accompany early stages of proteinuria in...
ORGANISM(S): Mus musculus 
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