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ProteomicsIdentify Novel Iron–Transporting Proteins in Streptococcus pneumoniae
Streptococcus pneumoniae (S. pneumoniae) is a major human pathogen causing morbidity and mortality worldwide. Efficiently acquiring iron from the environment is critical for S. pneumoniae to sustain growth and cause infection. There are only three known iron-uptake systems in Streptococcal species r...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2018-10-26 | PXD003313 | Pride
Streptococcus pneumoniae Iron–transporting proteins Proteomics 
ProteomicsA novel bactericidal mechanism of silver nanoparticles as a catalyst
iTRAQ based proteomics analysis revealed that proteins in E. coli might be oxidative damaged in AgNPs-L group.
ORGANISM(S): Escherichia coli 
2019-11-12 | PXD009674 | Pride
Itraq proteomics，agnps，e. coli 
ProteomicsAdaptiven mechanism of antibiotic resistant Staphylococus aureus to host environment
Antibiotic-resistant bacteria can escape from the killing of host immune and settle in the host to form persistent infections. In this study, we investigated the environmental adaptation mechanism of resistant Staphyloccus aureus (S. aureus) to host environment by Data-independent acquisition based ...
ORGANISM(S): Staphylococcus aureus 
2022-05-31 | PXD029584 | Pride
Host environment Ciprofloxacin-resistant Proteomics Staphylococcus aureus 
ProteomicsDirhodium (II) Complex Interferes with Iron-Transport System to Exert Antibacterial Action against Streptococcus pneumoniae
Drug resistance in bacteria is becoming a significant threat to global public health, and the development of novel and efficient antibacterial compounds is urgently needed. Recently, rhodium complexes have attracted attention as antimicrobial agents, yet their antibacterial mechanism remains unknown...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2022-02-28 | PXD011667 | Pride
Antibacterial mechanism Streptococcus pneumoniae Haem-transport system piuabcd Itraq Dirhodium (ii) complex 
ProteomicsMalignant hepatocellular carcinoma cells enrich translation regulatory proteins in exosomes
It is known that exosomes (endosome derived vesicles) play important roles in the formation of the tumor microenvironment. Hepatocellular carcinoma (HCC) is a highly malignant cancer, whose malignancy is largely influenced by the tumor microenvironment. The possible role and the specific content of ...
ORGANISM(S): Homo sapiens (Human) 
2017-07-18 | PXD004779 | Pride
Translatomics Exosome Super silac Proteomics Signaling pathway 
ProteomicsA Hidden Human Proteome Encoded by the “Non-Coding” Genes
It has been a long debate whether the 98% “non-coding” fraction of human genome can encode functional proteins besides a “random noise” of translation. We used our established translatome sequencing (RNC-seq) to analyze human cells and found that up to 3330 long non-coding RNAs (lncRNAs) were bound ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD005291 | Pride
New proteins，translating lncrnas 
ProteomicsTranslating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific
As a well-known phenomenon, total mRNAs poorly correlate to proteins in their abundances as reported. Recent findings calculated with bivariate models suggested even poorer such correlation, whereas focusing on the translating mRNAs (ribosome nascent-chain complex-bound mRNAs, RNC-mRNAs) subset. In ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD005299 | Pride
Translation ratios，translating mrnas 
ProteomicsFinding missing proteins from the epigenetically manipulated human cell with stringent quality criteria
There are three major epigenetic mechanisms, DNA methylation, histone modifications, and ncRNAs. The histone is a key player in epigenetics, and the acetylation and methylation are their most common post-translational modifications (PTMs). These histone modifications have important roles in transcri...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD002453 | Pride
Histone Chromosome-centric human proteome project Epigenetic Missing proteins 
TranscriptomicsTranscriptome and Translatome Profiling of Caco-2 cells
This experiment performed RNA-seq of transcriptome and translatome (translating mRNA) of Caco-2 cells We extracted transcriptome and translatome from Caco-2 cells and deep sequenced them
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-48603 | biostudies-arrayexpress
OtherIdentification of missing proteins defined by chromosome-centric proteome project in the cytoplasmic detergent-insoluble proteins
Data from ProteomeXchange, PXD ID: PXD001694. File: lungSILAC_first_14.mzml. Published as part of J Proteome Res. 2015 Jun 25 . From the Abstract: {{i}} ... As most samples prepared and analyzed in the C-HPP framework were focusing on detergent soluble proteins, we posit that as a natural compositi...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320016148 | GPMDB
Resource Reanalysis 
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