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MetabolomicsMetabolomic approaches to dissect dysregulated metabolism in the progression of pre-diabetes to T2DM

Most of pre-diabetes were eventually progress to diabetes, thereby profiling of prediabetic metabolic disorders may be an effective targeted preventive measure. We aimed to elucidate internal motivation of the progression of pre-diabetes to type 2 diabetes mellitus (T2DM) from a metabolic perspec...

2024-04-29 | MTBLS8644 | MetaboLights
TranscriptomicsT lymphocyte activation gene identification by coregulated expression on DNA microarrays
High-capacity methods for assessing gene function have become increasingly important because of the increasing number of newly identified genes emerging from large-scale genome sequencing and cDNA cloning efforts. We investigated the use of DNA microarrays to identify uncharacterized genes specifica...
ORGANISM(S): Homo sapiens 
2004-01-31 | E-GEOD-902 | biostudies-arrayexpress
TranscriptomicsFoxO1 Controls Effector to Memory Transition and Maintenance of Functional CD8 T-Cell Memory
During a T cell response, naïve CD8 T cells differentiate into effector cells. Subsequently, a subset of effector cells termed memory precursor effector cells (MPECs) further differentiates into functionally mature memory CD8 T cells. The transcriptional network underlying this carefully scripted p...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-45673 | biostudies-arrayexpress
TranscriptomicsHigh-time-resolution dynamic analysis of human regulatory T cell (Treg) / CD4+ T-effector cell (Teff) activation
Human FOXP3+CD25+CD4+ regulatory T cells (Tregs) play a dominant role in the maintenance of immune homeostasis. Several genes are known to be important for murine Tregs, but for human Tregs the genes and underlying molecular networks controlling the suppressor function still largely remain unclear. ...
ORGANISM(S): Homo sapiens 
2012-11-23 | E-GEOD-11292 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression analysis of T-cell prolymphocytic leukemia (T-PLL) patient samples
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. To characterize the gene expression profiles, 12 T-PLL MNC samples (>90% tumor cell content) were scr...
ORGANISM(S): Homo sapiens 
2017-09-08 | E-MTAB-5916 | biostudies-arrayexpress
ProteomicsAnalysis of Lysine Lactylation in CD4+ T cells of normal and EAU mouse
Primary CD4+ T cells were isolated from normal and EAU mice spleens and used for lactylome analysis.
ORGANISM(S): Mus musculus (Mouse) 
2023-08-29 | PXD040514 | Pride
Lactylation  cd4+ t cell  eau 
TranscriptomicsA cell atlas of human thymic development defines T cell repertoire formation
We performed single-cell RNA-sequencing to create a cell census of the human thymus during development, early childhood and adult life. We sampled 15 embryonic and fetal thymi spanning thymic developmental stages between 7 post-conception weeks (PCW) to 17 PCW, and 9 postnatal thymi from paediatric ...
ORGANISM(S): Mus musculus 
2020-02-21 | E-MTAB-8581 | biostudies-arrayexpress
TranscriptomicsTranscription profiling to compare Nodular lymphocyte predominant Hodgkins lymphoma and T cell/histiocyte rich B cell lymphoma
T-cell/histiocyte rich B cell lymphoma (THRBL) and nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) share some morphological characteristics, including a prominent stromal reaction, but display a markedly different prognosis. To investigate the difference between the stromal reactions of th...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-7788 | biostudies-arrayexpress
ProteomicsAMBRA1 controls the translation of immune-specific genes in T lymphocytes
T cell receptor (TCR) engagement causes a global cellular response that entrains signaling pathways, cell cycle regulation, and cell death. The molecular regulation of mRNA translation in these processes is poorly understood. During a whole-genome CRISPR screen for regulators of CD95 (Fas/APO-1)-med...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-08 | MSV000096042 | MassIVE
TranscriptomicsmiRNAs in activated mouse CD4 T cells by Bcl-6 overexpression
Compare miRNA expression profiles in mouse CD4 T cells overexpression of Bcl-6 vs empty vector Mouse naïve CD4+ T cells were transduced with a Bcl-6-expressing retrovirus or the control vector and cultured in Th0 condition for 2 days. Cells expressing medium to high levels of GFP were sorted and to...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-17000 | biostudies-arrayexpress
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