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MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (untargeted fecal metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4932 | MetaboLights
MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4933 | MetaboLights
ProteomicsCharacterization of lysine acetylome in mice subjected to chronic intermittent hypoxia
Chronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in ...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049226 |
ProteomicsChanges in the hippocampal proteome of chronic intermittent hypoxia mice
Cognitive and behavioural scales have indicated chronic intermittent hypoxia (CIH)-induced abnormalities in learning, memory, and cognition . Although earlier studies have shown that CIH impacts adult hippocampal neurogenesis and cognitive processes, the exact mechanism through which CIH affects hip...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049225 |
ProteomicsMulti-omics study on the effect of moderate intensity exercise on protein of lactylation in mouse muscle tissue
To explore the effects of moderate intensity exercise on protein of lactylation in mouse muscle tissue metabolism. The healthy adult mice running for 6 weeks as exercise model and sedentary mice as control were used to perform transcriptomic, proteomic, lactylation-proteomics, and metabolomics analy...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-10 | PXD053276 | Pride
Lysine malonylation polycystic ovary syndrome sirt4 granulosa cells metabolic pathway 
ProteomicsEffects of moderate intensity exercise on liver metabolism in mice based on multi-omics analysis
Background: Physical exercise is beneficial to keep physical and mental health. The molecular mechanisms underlying exercise are still worth exploring. Methods: The healthy adult mice after six weeks of moderate-intensity exercise (experimental group) and sedentary mice (control group) were used to ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-10 | PXD057080 | Pride
Lactylation Multi-omics Metabolome Liver Proteome Lchronic exercise 
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