Dataset Information

Changes in the hippocampal proteome of chronic intermittent hypoxia mice

ABSTRACT: Cognitive and behavioural scales have indicated chronic intermittent hypoxia (CIH)-induced abnormalities in learning, memory, and cognition . Although earlier studies have shown that CIH impacts adult hippocampal neurogenesis and cognitive processes, the exact mechanism through which CIH affects hippocampal function, particularly learning and memory, remains unclear. In this study, we employed Liquid chromatography-tandem mass spectrometry to examine the proteome of the hippocampus in mice exposed to CIH for or normoxia for 4 weeks. We identified 5729 proteins in the hippocampi of CIH and CON mice, 4878 of which were quantified via proteomic spectrogram analysis. Although numerous proteins were identified, only 21 proteins exhibited significant differences. In biological processes (BP) analysis, the majority of proteins were enriched in phagocytosis and immune response, especially in B cells. Furthermore, in the analysis of cellular components (CC), most of proteins showed enrichment in immunoglobulin complexes. Finally, in the analysis of molecular functions (MFs), a notable enrichment of these proteins in immunoglobulin receptor-binding activities was observed.

ORGANISM(S): Mus Musculus

SUBMITTER: Shan Wang

PROVIDER: PXD049225 | iProX | Wed Feb 07 00:00:00 GMT 2024

REPOSITORIES: iProX

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Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment.

Liu Fan F Yan Weiheng W Chen Chen C Zeng Yubing Y Kong Yaru Y He Xuejia X Pei Pei P Wang Shan S Zhang Ting T

Frontiers in molecular neuroscience 20240222

<h4>Introduction</h4>Chronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in the hippocampus and its specific effects on hippocampal function and behavior remain poorly understood.<h4>Methods</h4>To address this gap, we conducted a study using liquid chrom ...[more]

PMID: 38455734

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Changes in the hippocampal proteome of chronic intermittent hypoxia mice

Publications

Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment.

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