Changes in the hippocampal proteome of chronic intermittent hypoxia mice

ABSTRACT: Cognitive and behavioural scales have indicated chronic intermittent hypoxia (CIH)-induced abnormalities in learning, memory, and cognition . Although earlier studies have shown that CIH impacts adult hippocampal neurogenesis and cognitive processes, the exact mechanism through which CIH affects hippocampal function, particularly learning and memory, remains unclear. In this study, we employed Liquid chromatography-tandem mass spectrometry to examine the proteome of the hippocampus in mice exposed to CIH for or normoxia for 4 weeks. We identified 5729 proteins in the hippocampi of CIH and CON mice, 4878 of which were quantified via proteomic spectrogram analysis. Although numerous proteins were identified, only 21 proteins exhibited significant differences. In biological processes (BP) analysis, the majority of proteins were enriched in phagocytosis and immune response, especially in B cells. Furthermore, in the analysis of cellular components (CC), most of proteins showed enrichment in immunoglobulin complexes. Finally, in the analysis of molecular functions (MFs), a notable enrichment of these proteins in immunoglobulin receptor-binding activities was observed.

ORGANISM(S): Mus Musculus

SUBMITTER: Shan Wang  

PROVIDER: PXD049225 | iProX | Wed Feb 07 00:00:00 GMT 2024

REPOSITORIES: iProX