Gene-expression changes in cerium chloride-induced injury of mouse hippocampus

ABSTRACT: Our findings suggested that exposure to CeCl3 led to hippocampal lesions, apoptosis, oxidative stress and impairment of spatial recognition memory. Furthermore, microarray data showed marked alterations in the expression of 154 genes involved in learning and memory, immunity and inflammation, signal transduction, apoptosis and response to stress in the 2 mg/kg CeCl3 exposed hippocampi. Cerium is widely used in many aspects of modern society, including agriculture, industry and medicine. It has been demonstrated to enter the ecological environment, is then transferred to humans through food chains, and causes toxic actions in several organs including the brain of animals. However, the neurotoxic molecular mechanisms are not clearly understood. In this study, mice were exposed to 0.5, 1, and

ORGANISM(S): Mus musculus

SUBMITTER: fashui Hong 

PROVIDER: E-GEOD-44906 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress